• Gene id: 196403

Gene Summary

• Gene Symbol: DTX3   Gene   UCSC   Ensembl
• Aliases: RNF154, deltex3
• Gene name: deltex E3 ubiquitin ligase 3
• Alternate names: probable E3 ubiquitin-protein ligase DTX3, RING finger protein 154, RING-type E3 ubiquitin transferase DTX3, deltex 3, E3 ubiquitin ligase, deltex homolog 3, protein deltex-3,
• Gene location: 12q13.3 (57604326: 57609801)     Exons: 8     NC_000012.12
• Gene summary(Entrez): DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

Protein Summary

• Protein general information: Q8N9I9  
  • Name: Probable E3 ubiquitin protein ligase DTX3 (EC 2.3.2.27) (Protein deltex 3) (Deltex3) (RING finger protein 154) (RING type E3 ubiquitin transferase DTX3)
  • Length: 347  
  • Mass: 37988
• Sequence:

  MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGL
  YLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLP
  PRLREEAEEQESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDA
  TLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
  GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

• Structural information:
  • Interpro: IPR039396  IPR039399  IPR039398  IPR001841  IPR013083   IPR017907  
  • Prosite: PS00518 PS50089
  • CDD: cd09633
  • STRING: ENSP00000448696
• Other Databases: GeneCards:  DTX3  Malacards:  DTX3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016567	protein ubiquitination	IBA	biological process
GO:0005654	nucleoplasm	IBA	cellular component
GO:0007219	Notch signaling pathway	IBA	biological process
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0007219	Notch signaling pathway	IEA	biological process
GO:0016567	protein ubiquitination	IEA	biological process
GO:0007219	Notch signaling pathway	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007219	Notch signaling pathway	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04330	Notch signaling pathway

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R