• Gene id: 192670

Gene Summary

• Gene Symbol: AGO4   Gene   UCSC   Ensembl
• Aliases: EIF2C4
• Gene name: argonaute RISC component 4
• Alternate names: protein argonaute-4, argonaute 4, RISC catalytic component, argonaute RISC catalytic component 4, eukaryotic translation initiation factor 2C, 4,
• Gene location: 1p34.3 (35807629: 35857889)     Exons: 22     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related
• OMIM: 607356

Protein Summary

• Protein general information: Q9HCK5  
  • Name: Protein argonaute 4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF 2C 4) (eIF2C 4)
  • Length: 861  
  • Mass: 97097
• Sequence:

  MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQ
  IFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQ
  ALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMC
  EVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ
  YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKS
  NSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAP
  QKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVK
  RVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK
  PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSE
  GQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDF
  YLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHD
  SAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA

• Structural information:
  • Protein Domains: (225..33-)
    (/note="PAZ-)
    (/evidence="ECO:0000255|HAMAP-Rule:MF_03033-)
    (509..82-)
    (/note="Piwi-)
    (/evidence="ECO:0000255|HAMAP-Rule:MF_03033"-)
  • Interpro: IPR028604  IPR014811  IPR032472  IPR032473  IPR032474   IPR003100  IPR036085  IPR003165  IPR012337  IPR036397  
  • Prosite: PS50821 PS50822
  • PDB: 6OON
  • PDBsum: 6OON
  • STRING: ENSP00000362306
• Other Databases: GeneCards:  AGO4  Malacards:  AGO4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006417	regulation of translation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0007223	Wnt signaling pathway, calcium modulating pathway	TAS	biological process
GO:0010629	negative regulation of gene expression	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0010628	positive regulation of gene expression	TAS	biological process
GO:0035194	post-transcriptional gene silencing by RNA	TAS	biological process
GO:0045652	regulation of megakaryocyte differentiation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0010586	miRNA metabolic process	IEA	biological process
GO:0007140	male meiotic nuclear division	IEA	biological process
GO:0000932	P-body	IEA	cellular component
GO:0022604	regulation of cell morphogenesis	IEA	biological process
GO:0016442	RISC complex	IEA	cellular component
GO:0008584	male gonad development	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IMP	biological process
GO:0035198	miRNA binding	IDA	molecular function
GO:0003727	single-stranded RNA binding	IDA	molecular function
GO:0003725	double-stranded RNA binding	IDA	molecular function
GO:0010501	RNA secondary structure unwinding	IMP	biological process
GO:0031054	pre-miRNA processing	IDA	biological process
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	IDA	biological process
GO:0070578	RISC-loading complex	IDA	cellular component
GO:0010501	RNA secondary structure unwinding	IDA	biological process
GO:0016442	RISC complex	IDA	cellular component
GO:0090625	mRNA cleavage involved in gene silencing by siRNA	IDA	NOT|biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	IDA	NOT|biological process
GO:0016442	RISC complex	IDA	cellular component
GO:0000932	P-body	IEA	cellular component
GO:0035198	miRNA binding	IEA	molecular function
GO:0016442	RISC complex	IEA	cellular component
GO:0035278	miRNA mediated inhibition of translation	IEA	biological process
GO:0035278	miRNA mediated inhibition of translation	IDA	biological process
GO:0006402	mRNA catabolic process	IDA	biological process
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)