• Gene id: 1880

Gene Summary

• Gene Symbol: GPR183   Gene   UCSC   Ensembl
• Aliases: EBI2, hEBI2
• Gene name: G protein-coupled receptor 183
• Alternate names: G-protein coupled receptor 183, EBV-induced G-protein coupled receptor 2, Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor), epstein-Barr virus-induced G-protein coupled receptor 2,
• Gene location: 13q32.3 (99307398: 99294272)     Exons: 3     NC_000013.11
• Gene summary(Entrez): This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of
• OMIM: 605741

Protein Summary

• Protein general information: P32249  
  • Name: G protein coupled receptor 183 (Epstein Barr virus induced G protein coupled receptor 2) (EBI2) (EBV induced G protein coupled receptor 2) (hEBI2)
  • Length: 361  
  • Mass: 41224
  • Tissue specificity: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed
• Sequence:

  MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVI
  SDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKG
  VCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFR
  TAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
  CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK

• Structural information:
  • Interpro: IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • STRING: ENSP00000365596
• Other Databases: GeneCards:  GPR183  Malacards:  GPR183

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002312	B cell activation involved in immune response	IBA	biological process
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0008142	oxysterol binding	IDA	molecular function
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0030890	positive regulation of B cell proliferation	IDA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0008142	oxysterol binding	IDA	molecular function
GO:0008142	oxysterol binding	IDA	molecular function
GO:2000458	regulation of astrocyte chemotaxis	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0004930	G protein-coupled receptor activity	IDA	molecular function
GO:0004930	G protein-coupled receptor activity	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0004930	G protein-coupled receptor activity	IDA	molecular function
GO:0006959	humoral immune response	ISS	biological process
GO:0002313	mature B cell differentiation involved in immune response	ISS	biological process
GO:0008142	oxysterol binding	IMP	molecular function
GO:0061470	T follicular helper cell differentiation	ISS	biological process
GO:0036145	dendritic cell homeostasis	ISS	biological process
GO:0030316	osteoclast differentiation	ISS	biological process
GO:0010818	T cell chemotaxis	ISS	biological process
GO:0002407	dendritic cell chemotaxis	ISS	biological process
GO:0002250	adaptive immune response	ISS	biological process
GO:0030595	leukocyte chemotaxis	IMP	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0002250	adaptive immune response	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006955	immune response	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0008142	oxysterol binding	IEA	molecular function
GO:0006959	humoral immune response	IEA	biological process
GO:0002313	mature B cell differentiation involved in immune response	IEA	biological process
GO:0061470	T follicular helper cell differentiation	IEA	biological process
GO:0060326	cell chemotaxis	IEA	biological process
GO:0036145	dendritic cell homeostasis	IEA	biological process
GO:0030890	positive regulation of B cell proliferation	IEA	biological process
GO:0030595	leukocyte chemotaxis	IEA	biological process
GO:0030316	osteoclast differentiation	IEA	biological process
GO:0010818	T cell chemotaxis	IEA	biological process
GO:0002407	dendritic cell chemotaxis	IEA	biological process
GO:0002250	adaptive immune response	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)