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Gene id 187
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol APLNR   Gene   UCSC   Ensembl
Aliases AGTRL1, APJ, APJR, HG11
Gene name apelin receptor
Alternate names apelin receptor, APJ (apelin) receptor, APJ receptor, G protein-coupled receptor APJ, G-protein coupled receptor HG11, HG11 orphan receptor, angiotensin II receptor-like 1, angiotensin receptor-like 1,
Gene location 11q12.1 (57237452: 57233576)     Exons: 1     NC_000011.10
Gene summary(Entrez) This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against t
OMIM 120328

Protein Summary

Protein general information P35414  

Name: Apelin receptor (Angiotensin receptor like 1) (G protein coupled receptor APJ) (G protein coupled receptor HG11)

Length: 380  Mass: 42660

Tissue specificity: Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed

Sequence MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVAD
LTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVAT
AVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIA
QTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQE
TLVVD
Structural information
Interpro:  IPR003904  IPR000276  IPR017452  
Prosite:   PS00237 PS50262

PDB:  
2LOT 2LOU 2LOV 2LOW 5VBL
PDBsum:   2LOT 2LOU 2LOV 2LOW 5VBL
MINT:  
STRING:   ENSP00000475344
Other Databases GeneCards:  APLNR  Malacards:  APLNR

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0060182 apelin receptor activity
IBA molecular function
GO:0043951 negative regulation of cA
MP-mediated signaling
IBA biological process
GO:0007507 heart development
IBA biological process
GO:0007186 G protein-coupled recepto
r signaling pathway
IBA biological process
GO:0005886 plasma membrane
IBA cellular component
GO:0004930 G protein-coupled recepto
r activity
IBA molecular function
GO:0001568 blood vessel development
IBA biological process
GO:0005886 plasma membrane
IDA cellular component
GO:0001570 vasculogenesis
ISS biological process
GO:0060976 coronary vasculature deve
lopment
ISS biological process
GO:0007507 heart development
ISS biological process
GO:0007186 G protein-coupled recepto
r signaling pathway
IMP biological process
GO:0043951 negative regulation of cA
MP-mediated signaling
IMP biological process
GO:1904325 positive regulation of in
hibitory G protein-couple
d receptor phosphorylatio
n
IMP biological process
GO:0051281 positive regulation of re
lease of sequestered calc
ium ion into cytosol
IMP biological process
GO:0045766 positive regulation of an
giogenesis
IMP biological process
GO:1903589 positive regulation of bl
ood vessel endothelial ce
ll proliferation involved
in sprouting angiogenesi
s
ISS biological process
GO:0004930 G protein-coupled recepto
r activity
IEA molecular function
GO:0007186 G protein-coupled recepto
r signaling pathway
IEA biological process
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0001525 angiogenesis
IEA biological process
GO:0007165 signal transduction
IEA biological process
GO:0004930 G protein-coupled recepto
r activity
IEA molecular function
GO:0007369 gastrulation
IEA biological process
GO:0005886 plasma membrane
IEA cellular component
GO:0007275 multicellular organism de
velopment
IEA biological process
GO:0016032 viral process
IEA biological process
GO:0007186 G protein-coupled recepto
r signaling pathway
IEA biological process
GO:0016020 membrane
IEA cellular component
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0038023 signaling receptor activi
ty
TAS molecular function
GO:0004930 G protein-coupled recepto
r activity
TAS molecular function
GO:0005886 plasma membrane
TAS cellular component
GO:0005887 integral component of pla
sma membrane
TAS cellular component
GO:0007186 G protein-coupled recepto
r signaling pathway
TAS biological process
GO:0005886 plasma membrane
TAS cellular component
GO:0005886 plasma membrane
TAS cellular component
GO:0005886 plasma membrane
TAS cellular component
GO:0005886 plasma membrane
TAS cellular component
GO:0007186 G protein-coupled recepto
r signaling pathway
TAS biological process
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005515 protein binding
IPI molecular function
GO:1903589 positive regulation of bl
ood vessel endothelial ce
ll proliferation involved
in sprouting angiogenesi
s
IEA biological process
GO:0007512 adult heart development
IEA biological process
GO:0043951 negative regulation of cA
MP-mediated signaling
IEA biological process
GO:0016020 membrane
IEA cellular component
GO:0007186 G protein-coupled recepto
r signaling pathway
IEA biological process
GO:0005886 plasma membrane
IEA cellular component
GO:0060976 coronary vasculature deve
lopment
IEA biological process
GO:0001570 vasculogenesis
IEA biological process
GO:0050878 regulation of body fluid
levels
IEA biological process
GO:0005886 plasma membrane
IEA cellular component
GO:0060183 apelin receptor signaling
pathway
IEA biological process

KEGG pathways

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Pathway idPathway name
hsa04080Neuroactive ligand-receptor interaction
hsa04371Apelin signaling pathway
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract