• Gene id: 185

Gene Summary

• Gene Symbol: AGTR1   Gene   UCSC   Ensembl
• Aliases: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
• Gene name: angiotensin II receptor type 1
• Alternate names: type-1 angiotensin II receptor, type-1B angiotensin II receptor,
• Gene location: 3q24 (148697870: 148743002)     Exons: 5     NC_000003.12
• Gene summary(Entrez): Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene enc
• OMIM: 106165

Protein Summary

• Protein general information: P30556  
  • Name: Type 1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type 1 receptor) (AT1)
  • Length: 359  
  • Mass: 41061
  • Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas.
• Sequence:

  MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADL
  CFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCI
  IIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA
  YEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
  FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

• Structural information:
  • Interpro: IPR000190  IPR000248  IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • PDB: 1ZV0 4YAY 4ZUD 6DO1
  • PDBsum: 1ZV0 4YAY 4ZUD 6DO1
  • STRING: ENSP00000419422
• Other Databases: GeneCards:  AGTR1  Malacards:  AGTR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001596	angiotensin type I receptor activity	IBA	molecular function
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0006954	inflammatory response	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	biological process
GO:0007266	Rho protein signal transduction	IDA	biological process
GO:0004945	angiotensin type II receptor activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0004945	angiotensin type II receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0019229	regulation of vasoconstriction	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001596	angiotensin type I receptor activity	IDA	molecular function
GO:0004945	angiotensin type II receptor activity	IDA	molecular function
GO:0031711	bradykinin receptor binding	IPI	molecular function
GO:0001596	angiotensin type I receptor activity	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0046982	protein heterodimerization activity	IPI	molecular function
GO:0002034	regulation of blood vessel diameter by renin-angiotensin	IC	biological process
GO:0010744	positive regulation of macrophage derived foam cell differentiation	IC	biological process
GO:0097746	regulation of blood vessel diameter	IC	biological process
GO:0050727	regulation of inflammatory response	IC	biological process
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	IDA	biological process
GO:0001558	regulation of cell growth	NAS	biological process
GO:0001822	kidney development	IMP	biological process
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	NAS	biological process
GO:0032270	positive regulation of cellular protein metabolic process	IMP	biological process
GO:0033864	positive regulation of NAD(P)H oxidase activity	TAS	biological process
GO:0035813	regulation of renal sodium excretion	NAS	biological process
GO:0042127	regulation of cell population proliferation	NAS	biological process
GO:0050729	positive regulation of inflammatory response	TAS	biological process
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IC	biological process
GO:0005887	integral component of plasma membrane	IC	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	biological process
GO:0019229	regulation of vasoconstriction	IC	biological process
GO:0019229	regulation of vasoconstriction	IDA	biological process
GO:0019722	calcium-mediated signaling	IDA	biological process
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	biological process
GO:0038166	angiotensin-activated signaling pathway	IDA	biological process
GO:0002018	renin-angiotensin regulation of aldosterone production	NAS	biological process
GO:0010873	positive regulation of cholesterol esterification	IMP	biological process
GO:0019229	regulation of vasoconstriction	NAS	biological process
GO:0032430	positive regulation of phospholipase A2 activity	IMP	biological process
GO:0034374	low-density lipoprotein particle remodeling	NAS	biological process
GO:2000379	positive regulation of reactive oxygen species metabolic process	TAS	biological process
GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0060326	cell chemotaxis	IDA	biological process
GO:0016021	integral component of membrane	NAS	cellular component
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa04080	Neuroactive ligand-receptor interaction
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04934	Cushing syndrome
hsa04072	Phospholipase D signaling pathway
hsa04371	Apelin signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04925	Aldosterone synthesis and secretion
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa04924	Renin secretion
hsa04927	Cortisol synthesis and secretion
hsa04614	Renin-angiotensin system

Diseases

Associated diseases	References
Cancer	GAD: 20026870
Atherosclerosis	GAD: 12394950
Cardiovascular disease	GAD: 12394950
Cerebral infarction	GAD: 12394950
Coronary heart disease	GAD: 12394950
Hypertension	GAD: 12394950
Polycystic kidney disease	GAD: 15628301
Glaucoma	GAD: 12556231
Hemolytic uremic syndrome	GAD: 19110485
Periodontitis	GAD: 19162259
Diabetes	GAD: 15332573
Fatty liver	GAD: 19302184
Hypercholesterolemia	GAD: 12394950
Metabolic syndrome	GAD: 12394950
Migraine disorder	GAD: 19178574
Stroke	GAD: 12394950
Alzheimer's disease	GAD: 19141999
Amyotrophic lateral sclerosis (ALS)	GAD: 18513389
Autonomic nervous system diseases	GAD: 16954165
Cerebral palsy	GAD: 19238444
Otosclerosis	GAD: 18491423
Dementia	GAD: 16603315
Depression	GAD: 17499413
Several psychiatric disorders	GAD: 19086053
Chronic glomerulonephritis	GAD: 11865575
Kidney diseases	GAD: 12579398
Preeclampsia	GAD: 15221785
Recurrent pregnancy loss (RPL)	GAD: 15212666
Endometriosis	INFBASE: 19524223
Premature ovarian insufficiency (POI)	INFBASE: 23615648
Poor ovarian reserve (PR)	INFBASE: 19524223
Polycystic ovary syndrome (PCOS)	INFBASE: 23564192
No ovarian factor (NOF)	INFBASE: 19524223
Polycystic ovary syndrome (PCOS)	INFBASE: 19524223
Chronic obstructive pulmonary disease (COPD)	GAD: 15193960
Renal tubular dysgenesis	KEGG: H00575
Renal tubular dysgenesis	OMIM: 106165
Nephropathy	GAD: 12476891
Renal tubular dysgenesis	KEGG:H00575
Renal tubular dysgenesis	KEGG:H00575
Atrial fibrillation	PMID:20080265
Alzheimer's disease	PMID:8666063
Alzheimer's disease	PMID:21929736
Hypertension	PMID:16519598
Essential hypertension	PMID:18604484
Sarcoidosis	PMID:20560294
Huntington's disease	PMID:8666063
Parkinson's disease	PMID:8666063
Breast cancer	PMID:23828384
Coronary artery disease	PMID:12975417
Carotid artery disease	PMID:16519598
renal cell carcinoma	PMID:21102591
Myocardial infarction	PMID:16061119
Pulmonary hypertension	PMID:19332265
cerebrovascular disease	PMID:16109907
Chronic kidney disease	PMID:12832734
intermediate coronary syndrome	PMID:11451295
Vesicoureteral reflux	PMID:11819209
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)