|
Gene id |
1846 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
DUSP4 Gene UCSC Ensembl |
|
Aliases |
HVH2, MKP-2, MKP2, TYP |
|
Gene name |
dual specificity phosphatase 4 |
|
Alternate names |
dual specificity protein phosphatase 4, MAP kinase phosphatase 2, VH1 homologous phosphatase 2, dual specificity protein phosphatase hVH2, mitogen-activated protein kinase phosphatase 2, serine/threonine specific protein phosphatase, |
|
Gene location |
8p12 (29350683: 29333061) Exons: 5 NC_000005.10
|
|
Gene summary(Entrez) |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
|
|
OMIM |
602747 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04010 | MAPK signaling pathway | |
|
| Associated diseases |
References |
| May play an important role in spermatogenesis and/or meiosis | MIK: 9407093 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| May play an important role in spermatogenesis and/or meiosis | MIK: 9407093 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 9407093 |
May play a
n importan
t role in
spermatoge
nesis and/
or meiosis
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|