• Gene id: 1814

Gene Summary

• Gene Symbol: DRD3   Gene   UCSC   Ensembl
• Aliases: D3DR, ETM1, FET1
• Gene name: dopamine receptor D3
• Alternate names: D(3) dopamine receptor, essential tremor 1,
• Gene location: 3q13.31 (114199406: 114127579)     Exons: 10     NC_000003.12
• Gene summary(Entrez): This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated wi
• OMIM: 611746

Protein Summary

• Protein general information: P35462  
  • Name: D(3) dopamine receptor (Dopamine D3 receptor)
  • Length: 400  
  • Mass: 44225
  • Tissue specificity: Brain.
• Sequence:

  MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD
  LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRV
  ALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILT
  RQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
  LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVN
  SALNPVIYTTFNIEFRKAFLKILSC

• Structural information:
  • Interpro: IPR001620  IPR000929  IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • PDB: 3PBL
  • PDBsum: 3PBL
  • DIP: 5976
  • STRING: ENSP00000373169
• Other Databases: GeneCards:  DRD3  Malacards:  DRD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IDA	cellular component
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IBA	biological process
GO:0007267	cell-cell signaling	IBA	biological process
GO:0014059	regulation of dopamine secretion	IBA	biological process
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IBA	biological process
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	biological process
GO:1901386	negative regulation of voltage-gated calcium channel activity	IBA	biological process
GO:0001963	synaptic transmission, dopaminergic	IBA	biological process
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007194	negative regulation of adenylate cyclase activity	IBA	biological process
GO:0043266	regulation of potassium ion transport	IBA	biological process
GO:0051481	negative regulation of cytosolic calcium ion concentration	IBA	biological process
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	biological process
GO:0051967	negative regulation of synaptic transmission, glutamatergic	IBA	biological process
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004952	dopamine neurotransmitter receptor activity	IEA	molecular function
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0098691	dopaminergic synapse	IEA	cellular component
GO:0060160	negative regulation of dopamine receptor signaling pathway	IEA	biological process
GO:0051580	regulation of neurotransmitter uptake	IEA	biological process
GO:0048715	negative regulation of oligodendrocyte differentiation	IEA	biological process
GO:0048148	behavioral response to cocaine	IEA	biological process
GO:0045776	negative regulation of blood pressure	IEA	biological process
GO:0043278	response to morphine	IEA	biological process
GO:0040014	regulation of multicellular organism growth	IEA	biological process
GO:0019216	regulation of lipid metabolic process	IEA	biological process
GO:0014059	regulation of dopamine secretion	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IEA	biological process
GO:0002016	regulation of blood volume by renin-angiotensin	IEA	biological process
GO:0001975	response to amphetamine	IEA	biological process
GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0090325	regulation of locomotion involved in locomotory behavior	IEA	biological process
GO:0048148	behavioral response to cocaine	IEA	biological process
GO:0045187	regulation of circadian sleep/wake cycle, sleep	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0035483	gastric emptying	IEA	biological process
GO:0008284	positive regulation of cell population proliferation	IEA	biological process
GO:0007212	dopamine receptor signaling pathway	IEA	biological process
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA	biological process
GO:0004952	dopamine neurotransmitter receptor activity	IEA	molecular function
GO:0001963	synaptic transmission, dopaminergic	IEA	biological process
GO:0060161	positive regulation of dopamine receptor signaling pathway	IEA	biological process
GO:0051898	negative regulation of protein kinase B signaling	IEA	biological process
GO:0050883	musculoskeletal movement, spinal reflex action	IEA	biological process
GO:0042220	response to cocaine	IEA	biological process
GO:0032922	circadian regulation of gene expression	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0008542	visual learning	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA	molecular function
GO:0099061	integral component of postsynaptic density membrane	IEA	cellular component
GO:0098982	GABA-ergic synapse	IEA	cellular component
GO:0046717	acid secretion	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0045840	positive regulation of mitotic nuclear division	IEA	biological process
GO:0042493	response to drug	IEA	biological process
GO:0040012	regulation of locomotion	IEA	biological process
GO:0035815	positive regulation of renal sodium excretion	IEA	biological process
GO:0035240	dopamine binding	IEA	molecular function
GO:0032416	negative regulation of sodium:proton antiporter activity	IEA	biological process
GO:0031748	D1 dopamine receptor binding	IEA	molecular function
GO:0030139	endocytic vesicle	IEA	cellular component
GO:0019904	protein domain specific binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0008144	drug binding	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0006914	autophagy	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0002031	G protein-coupled receptor internalization	IEA	biological process
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008144	drug binding	ISS	molecular function
GO:0006874	cellular calcium ion homeostasis	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA	biological process
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA	biological process
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA	biological process
GO:0042417	dopamine metabolic process	IC	biological process
GO:0007611	learning or memory	NAS	biological process
GO:0007626	locomotory behavior	ISS	biological process
GO:0014059	regulation of dopamine secretion	ISS	biological process
GO:0035176	social behavior	NAS	biological process
GO:0043278	response to morphine	ISS	biological process
GO:0045471	response to ethanol	ISS	NOT|biological process
GO:0045776	negative regulation of blood pressure	ISS	biological process
GO:0048148	behavioral response to cocaine	ISS	biological process
GO:0048148	behavioral response to cocaine	IEP	biological process
GO:0048715	negative regulation of oligodendrocyte differentiation	ISS	biological process
GO:0002031	G protein-coupled receptor internalization	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005887	integral component of plasma membrane	IC	cellular component
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0034776	response to histamine	IDA	biological process
GO:0050482	arachidonic acid secretion	IDA	biological process
GO:0050709	negative regulation of protein secretion	IDA	biological process
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	IC	biological process
GO:0007612	learning	NAS	biological process
GO:0008542	visual learning	ISS	biological process
GO:0032922	circadian regulation of gene expression	ISS	biological process
GO:0042220	response to cocaine	IEP	biological process
GO:0042493	response to drug	ISS	biological process
GO:0045840	positive regulation of mitotic nuclear division	ISS	biological process
GO:0046717	acid secretion	ISS	biological process
GO:0050883	musculoskeletal movement, spinal reflex action	ISS	biological process
GO:0051898	negative regulation of protein kinase B signaling	ISS	biological process
GO:0060134	prepulse inhibition	IMP	biological process
GO:0060161	positive regulation of dopamine receptor signaling pathway	ISS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0032467	positive regulation of cytokinesis	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04728	Dopaminergic synapse

Diseases

Associated diseases	References
Schizophrenia	KEGG:H01649
Schizophrenia	KEGG:H01649
Alzheimer's disease	PMID:17182012
Parkinson's disease	PMID:10495037
Schizophrenia	PMID:1362221
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881