• Gene id: 1812

Gene Summary

• Gene Symbol: DRD1   Gene   UCSC   Ensembl
• Aliases: DADR, DRD1A
• Gene name: dopamine receptor D1
• Alternate names: D(1A) dopamine receptor, dopamine D1 receptor,
• Gene location: 5q35.2 (175444181: 175440035)     Exons: 2     NC_000005.10
• Gene summary(Entrez): This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases.

Protein Summary

• Protein general information: P21728  
  • Name: D(1A) dopamine receptor (Dopamine D1 receptor)
  • Length: 446  
  • Mass: 49293
  • Tissue specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO
• Sequence:

  MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAV
  LVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTL
  SVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQI
  RRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
  GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHH
  EPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT

• Structural information:
  • Interpro: IPR001413  IPR000929  IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • PDB: 1OZ5
  • PDBsum: 1OZ5
  • STRING: ENSP00000377353
• Other Databases: GeneCards:  DRD1  Malacards:  DRD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0097730	non-motile cilium	IDA	cellular component
GO:0060170	ciliary membrane	IDA	cellular component
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0007212	dopamine receptor signaling pathway	IBA	biological process
GO:0007267	cell-cell signaling	IBA	biological process
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	biological process
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IBA	molecular function
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0004952	dopamine neurotransmitter receptor activity	IEA	molecular function
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0042311	vasodilation	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0004952	dopamine neurotransmitter receptor activity	IDA	molecular function
GO:0005929	cilium	IDA	cellular component
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IGI	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IEA	molecular function
GO:0001659	temperature homeostasis	IEA	biological process
GO:0001661	conditioned taste aversion	IEA	biological process
GO:0001932	regulation of protein phosphorylation	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0006606	protein import into nucleus	IEA	biological process
GO:0006936	muscle contraction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0007190	activation of adenylate cyclase activity	IEA	biological process
GO:0007612	learning	IEA	biological process
GO:0007625	grooming behavior	IEA	biological process
GO:0007628	adult walking behavior	IEA	biological process
GO:0007631	feeding behavior	IEA	biological process
GO:0008306	associative learning	IEA	biological process
GO:0008542	visual learning	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0021853	cerebral cortex GABAergic interneuron migration	IEA	biological process
GO:0042220	response to cocaine	IEA	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042711	maternal behavior	IEA	biological process
GO:0043197	dendritic spine	IEA	cellular component
GO:0046959	habituation	IEA	biological process
GO:0046960	sensitization	IEA	biological process
GO:0060292	long-term synaptic depression	IEA	biological process
GO:0098982	GABA-ergic synapse	IEA	cellular component
GO:0099056	integral component of presynaptic membrane	IEA	cellular component
GO:0001662	behavioral fear response	IEA	biological process
GO:0001963	synaptic transmission, dopaminergic	IEA	biological process
GO:0001975	response to amphetamine	IEA	biological process
GO:0004952	dopamine neurotransmitter receptor activity	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IEA	biological process
GO:0007212	dopamine receptor signaling pathway	IEA	biological process
GO:0007613	memory	IEA	biological process
GO:0007617	mating behavior	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0012505	endomembrane system	IEA	cellular component
GO:0014002	astrocyte development	IEA	biological process
GO:0015872	dopamine transport	IEA	biological process
GO:0019226	transmission of nerve impulse	IEA	biological process
GO:0019228	neuronal action potential	IEA	biological process
GO:0021542	dentate gyrus development	IEA	biological process
GO:0021756	striatum development	IEA	biological process
GO:0021766	hippocampus development	IEA	biological process
GO:0030335	positive regulation of cell migration	IEA	biological process
GO:0030432	peristalsis	IEA	biological process
GO:0035106	operant conditioning	IEA	biological process
GO:0042053	regulation of dopamine metabolic process	IEA	biological process
GO:0043987	histone H3-S10 phosphorylation	IEA	biological process
GO:0046323	glucose import	IEA	biological process
GO:0048148	behavioral response to cocaine	IEA	biological process
GO:0051968	positive regulation of synaptic transmission, glutamatergic	IEA	biological process
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IEA	biological process
GO:0060291	long-term synaptic potentiation	IEA	biological process
GO:0097731	9+0 non-motile cilium	IEA	cellular component
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0099055	integral component of postsynaptic membrane	IEA	cellular component
GO:2000300	regulation of synaptic vesicle exocytosis	IEA	biological process
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IDA	molecular function
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IDA	molecular function
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IMP	molecular function
GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035240	dopamine binding	IMP	molecular function
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0042417	dopamine metabolic process	IC	biological process
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IDA	biological process
GO:0071870	cellular response to catecholamine stimulus	IDA	biological process
GO:0007617	mating behavior	ISS	biological process
GO:0019226	transmission of nerve impulse	ISS	biological process
GO:0030335	positive regulation of cell migration	ISS	biological process
GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISS	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005887	integral component of plasma membrane	IC	cellular component
GO:0007190	activation of adenylate cyclase activity	IDA	biological process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IDA	biological process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	IDA	biological process
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	biological process
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	IC	biological process
GO:0007416	synapse assembly	ISS	biological process
GO:0007628	adult walking behavior	ISS	biological process
GO:0008542	visual learning	ISS	biological process
GO:0021853	cerebral cortex GABAergic interneuron migration	ISS	biological process
GO:0042493	response to drug	ISS	biological process
GO:0043268	positive regulation of potassium ion transport	ISS	biological process
GO:0060134	prepulse inhibition	ISS	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0043197	dendritic spine	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:1903351	cellular response to dopamine	IMP	biological process
GO:0010628	positive regulation of gene expression	IMP	biological process
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IDA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0043197	dendritic spine	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa05012	Parkinson disease
hsa04024	cAMP signaling pathway
hsa04020	Calcium signaling pathway
hsa05034	Alcoholism
hsa04728	Dopaminergic synapse
hsa05032	Morphine addiction
hsa04540	Gap junction
hsa05031	Amphetamine addiction
hsa05030	Cocaine addiction

Diseases

Associated diseases	References
Alzheimer's disease	PMID:17182012
Kidney failure	PMID:19675531
Hypertension	PMID:10948075
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R