• Gene id: 171169

Gene Summary

• Gene Symbol: SPACA4   Gene   UCSC   Ensembl
• Aliases: SAMP14
• Gene name: sperm acrosome associated 4
• Alternate names: sperm acrosome membrane-associated protein 4, sperm acrosomal membrane protein 14, sperm acrosomal membrane-associated protein 14, testicular tissue protein Li 167,
• Gene location: 19q13.33 (48606741: 48607713)     Exons: 1     NC_000019.10
• OMIM: 609932

Protein Summary

• Protein general information: Q8TDM5  
  • Name: Sperm acrosome membrane associated protein 4 (Sperm acrosomal membrane associated protein 14)
  • Length: 124  
  • Mass: 13004
  • Tissue specificity: Testis specific (PubMed
• Sequence:

  MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEE
  PVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL

• Structural information:
  • Protein Domains: (23..9-)
    (/note="UPAR/Ly6"-)
  • Interpro: IPR016054  
  • STRING: ENSP00000312774
• Other Databases: GeneCards:  SPACA4  Malacards:  SPACA4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0031225	anchored component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0001669	acrosomal vesicle	IEA	cellular component

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)