Gene id |
169026 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
SLC30A8 Gene UCSC Ensembl |
Aliases |
ZNT8, ZnT-8 |
Gene name |
solute carrier family 30 member 8 |
Alternate names |
zinc transporter 8, solute carrier family 30 (zinc transporter), member 8, zinc transporter ZnT-8, |
Gene location |
8q24.11 (116950216: 117176713) Exons: 13 NC_000008.11
|
Gene summary(Entrez) |
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalize
|
OMIM |
611145 |
Protein Summary
|
Protein general information
| Q8IWU4
Name: Zinc transporter 8 (ZnT 8) (Solute carrier family 30 member 8)
Length: 369 Mass: 40755
Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in s
|
Sequence |
MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPTEKGANEYAYAKWKLC SASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILC IWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDL FQSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSV HSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD
|
Structural information |
|
Other Databases |
GeneCards: SLC30A8 Malacards: SLC30A8 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0005886 |
plasma membrane
|
IBA |
cellular component |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
IBA |
molecular function |
GO:0009749 |
response to glucose
|
IBA |
biological process |
GO:0010043 |
response to zinc ion
|
IBA |
biological process |
GO:0030073 |
insulin secretion
|
IBA |
biological process |
GO:0061088 |
regulation of sequesterin g of zinc ion
|
IBA |
biological process |
GO:0071577 |
zinc ion transmembrane tr ansport
|
IBA |
biological process |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
IEA |
molecular function |
GO:0006812 |
cation transport
|
IEA |
biological process |
GO:0006882 |
cellular zinc ion homeost asis
|
IEA |
biological process |
GO:0008324 |
cation transmembrane tran sporter activity
|
IEA |
molecular function |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0055085 |
transmembrane transport
|
IEA |
biological process |
GO:0031410 |
cytoplasmic vesicle
|
IEA |
cellular component |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0006829 |
zinc ion transport
|
IEA |
biological process |
GO:0006811 |
ion transport
|
IEA |
biological process |
GO:0030667 |
secretory granule membran e
|
TAS |
cellular component |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
TAS |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0032024 |
positive regulation of in sulin secretion
|
IEA |
biological process |
GO:0009749 |
response to glucose
|
IEA |
biological process |
GO:0006882 |
cellular zinc ion homeost asis
|
IEA |
biological process |
GO:0070555 |
response to interleukin-1
|
IEA |
biological process |
GO:0061088 |
regulation of sequesterin g of zinc ion
|
IEA |
biological process |
GO:0060627 |
regulation of vesicle-med iated transport
|
IEA |
biological process |
GO:0034341 |
response to interferon-ga mma
|
IEA |
biological process |
GO:0031410 |
cytoplasmic vesicle
|
IEA |
cellular component |
GO:0030073 |
insulin secretion
|
IEA |
biological process |
GO:0042803 |
protein homodimerization activity
|
IEA |
molecular function |
GO:0031410 |
cytoplasmic vesicle
|
IEA |
cellular component |
GO:0030073 |
insulin secretion
|
IEA |
biological process |
GO:0009749 |
response to glucose
|
IEA |
biological process |
GO:0006882 |
cellular zinc ion homeost asis
|
IEA |
biological process |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
IDA |
molecular function |
GO:0008270 |
zinc ion binding
|
IC |
molecular function |
GO:0042803 |
protein homodimerization activity
|
ISS |
molecular function |
GO:0005794 |
Golgi apparatus
|
IDA |
NOT|cellular component |
GO:0030141 |
secretory granule
|
IDA |
cellular component |
GO:0032119 |
sequestering of zinc ion
|
IDA |
biological process |
GO:0005886 |
plasma membrane
|
IDA |
cellular component |
GO:0006829 |
zinc ion transport
|
IDA |
biological process |
GO:0006882 |
cellular zinc ion homeost asis
|
ISS |
biological process |
GO:0006882 |
cellular zinc ion homeost asis
|
ISS |
biological process |
GO:0009749 |
response to glucose
|
IMP |
biological process |
GO:0031410 |
cytoplasmic vesicle
|
ISS |
cellular component |
GO:0030073 |
insulin secretion
|
IMP |
biological process |
GO:0042593 |
glucose homeostasis
|
ISS |
NOT|biological process |
GO:0060627 |
regulation of vesicle-med iated transport
|
ISS |
biological process |
GO:0061088 |
regulation of sequesterin g of zinc ion
|
ISS |
biological process |
GO:0032024 |
positive regulation of in sulin secretion
|
ISS |
biological process |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0030658 |
transport vesicle membran e
|
IEA |
cellular component |
|
|
Associated diseases |
References |
Type 2 diabetes mellitus | KEGG:H00409 |
Type 2 diabetes mellitus | KEGG:H00409 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
13 (5 controls, 8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
|