• Gene id: 167227

Gene Summary

• Gene Symbol: DCP2   Gene   UCSC   Ensembl
• Aliases: NUDT20
• Gene name: decapping mRNA 2
• Alternate names: m7GpppN-mRNA hydrolase, DCP2 decapping enzyme homolog, hDpc, mRNA-decapping enzyme 2, nudix (nucleoside diphosphate linked moiety X)-type motif 20,
• Gene location: 5q22.2 (47381000: 47413434)     Exons: 25     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to
• OMIM: 609844

Protein Summary

• Protein general information: Q8IU60  
  • Name: m7GpppN mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate linked moiety X motif 20) (Nudix motif 20) (mRNA decapping enzyme 2) (hDpc)
  • Length: 420  
  • Mass: 48423
  • Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level). {ECO
• Sequence:

  METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPF
  LLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETG
  FDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKF
  FMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKP
  YNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKLQDNFETDAVYDLPSS
  SEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL

• Structural information:
  • Protein Domains: (95..22-)
    (/note="Nudix-hydrolase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00794"-)
  • Interpro: IPR007722  IPR036189  IPR015797  IPR020084  IPR000086  
  • Prosite: PS51462 PS00893
  • PDB: 5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
  • PDBsum: 5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
  • DIP: 31126
  • STRING: ENSP00000373715
• Other Databases: GeneCards:  DCP2  Malacards:  DCP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA	biological process
GO:0000932	P-body	IBA	cellular component
GO:0050072	m7G(5')pppN diphosphatase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0050072	m7G(5')pppN diphosphatase activity	IDA	molecular function
GO:0050072	m7G(5')pppN diphosphatase activity	IDA	molecular function
GO:0043488	regulation of mRNA stability	IDA	biological process
GO:0006402	mRNA catabolic process	IDA	biological process
GO:0006402	mRNA catabolic process	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0030145	manganese ion binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000932	P-body	IDA	cellular component
GO:0016442	RISC complex	IDA	cellular component
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	TAS	molecular function
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006402	mRNA catabolic process	IEA	biological process
GO:0070034	telomerase RNA binding	IC	molecular function
GO:0004534	5'-3' exoribonuclease activity	IMP	molecular function
GO:1904872	regulation of telomerase RNA localization to Cajal body	IMP	biological process
GO:0032211	negative regulation of telomere maintenance via telomerase	IMP	biological process
GO:0000932	P-body	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process
GO:0071044	histone mRNA catabolic process	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation

Diseases

Associated diseases	References
Male infertility	MIK: 32245620
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
32245620	Male infertility				Male infertility