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Gene id 1668
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol DEFA3   Gene   UCSC   Ensembl
Aliases DEF3, HNP-3, HNP3, HP-3, HP3
Gene name defensin alpha 3
Alternate names neutrophil defensin 3, defensin 3, neutrophil-specific, defensin, alpha 3, neutrophil-specific, neutrophil peptide 3,
Gene location 8p23.1 (112254721: 112107930)     Exons: 40     NC_000006.12
Gene summary(Entrez) Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract,
OMIM 604522

Protein Summary

Protein general information P59666  

Name: Neutrophil defensin 3 (Defensin, alpha 3) (HNP 3) (HP 3) (HP3) [Cleaved into: HP 3 56; Neutrophil defensin 2 (HNP 2) (HP 2) (HP2)]

Length: 94  Mass: 10245

Sequence MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIA
GERRYGTCIYQGRLWAFCC
Structural information
Interpro:  IPR006081  IPR016327  IPR006080  IPR002366  
Prosite:   PS00269

PDB:  
1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5
PDBsum:   1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5
STRING:   ENSP00000328359
Other Databases GeneCards:  DEFA3  Malacards:  DEFA3

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0002227 innate immune response in
mucosa
IBA biological process
GO:0005615 extracellular space
IBA cellular component
GO:0019731 antibacterial humoral res
ponse
IBA biological process
GO:0050830 defense response to Gram-
positive bacterium
IBA biological process
GO:0061844 antimicrobial humoral imm
une response mediated by
antimicrobial peptide
IBA biological process
GO:0071222 cellular response to lipo
polysaccharide
IBA biological process
GO:0050829 defense response to Gram-
negative bacterium
IBA biological process
GO:0051673 membrane disruption in ot
her organism
IBA biological process
GO:0005576 extracellular region
IEA cellular component
GO:0005615 extracellular space
IEA cellular component
GO:0006952 defense response
IEA biological process
GO:0031640 killing of cells of other
organism
IEA biological process
GO:0050832 defense response to fungu
s
IEA biological process
GO:0006952 defense response
IEA biological process
GO:0005576 extracellular region
IEA cellular component
GO:0051607 defense response to virus
IEA biological process
GO:0042742 defense response to bacte
rium
IEA biological process
GO:0019730 antimicrobial humoral res
ponse
TAS biological process
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005796 Golgi lumen
TAS cellular component
GO:0005796 Golgi lumen
TAS cellular component
GO:0005796 Golgi lumen
TAS cellular component
GO:0035578 azurophil granule lumen
TAS cellular component
GO:0035578 azurophil granule lumen
TAS cellular component
GO:0005576 extracellular region
IEA cellular component
GO:0019731 antibacterial humoral res
ponse
IDA biological process
GO:0005615 extracellular space
IDA cellular component
GO:0050830 defense response to Gram-
positive bacterium
IDA biological process
GO:0005615 extracellular space
IDA cellular component
GO:0002227 innate immune response in
mucosa
IDA biological process
GO:0030520 intracellular estrogen re
ceptor signaling pathway
IDA biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0061844 antimicrobial humoral imm
une response mediated by
antimicrobial peptide
IC biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0031640 killing of cells of other
organism
IDA biological process
GO:0061844 antimicrobial humoral imm
une response mediated by
antimicrobial peptide
IDA biological process
GO:0042803 protein homodimerization
activity
IDA molecular function
GO:0003674 molecular_function
ND molecular function
GO:0005615 extracellular space
HDA cellular component
GO:0070062 extracellular exosome
HDA cellular component

KEGG pathways

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Pathway idPathway name
hsa04621NOD-like receptor signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05150Staphylococcus aureus infection
Associated diseases References
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract