• Gene id: 164832

Gene Summary

• Gene Symbol: LONRF2   Gene   UCSC   Ensembl
• Aliases: RNF192
• Gene name: LON peptidase N-terminal domain and ring finger 2
• Alternate names: LON peptidase N-terminal domain and RING finger protein 2, RING finger protein 192, neuroblastoma apoptosis-related protease,
• Gene location: 2q11.2 (100322500: 100271874)     Exons: 13     NC_000002.12
• OMIM: 605745

Protein Summary

• Protein general information: Q1L5Z9  
  • Name: LON peptidase N terminal domain and RING finger protein 2 (Neuroblastoma apoptosis related protease) (RING finger protein 192)
  • Length: 754  
  • Mass: 83654
• Sequence:

  MSPEPVPPPPPPQCPGCDRAEPIAQRLEEGDEAFRAGDYEMAAELFRSMLAGLAQPDRGLCLRLGDALARAGRLP
  EALGAFRGAARLGALRPEELEELAGGLVRAVGLRDRPLSAENPGGEPEAPGEGGPAPEPRAPRDLLGCPRCRRLL
  HKPVTLPCGLTVCKRCVEPGPARPQVRRVNVVLSGLLEKCFPAECRLRRLAGQARSLQRQQQPEAALLRCDQALE
  LAPDDNSLLLLRAELYLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNS
  VKKEAQKVMCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEKSDMLGNTNSSVLYFI
  LGLHFEEDKKALESILPTAPSAGLKRQFPDDVEDAPDLNAPGKIPKKDLSLQRSPNSETEESQGLSLDVTDFECA
  LCMRLLFEPVTTPCGHTFCLKCLERCLDHAPHCPLCKDKLSELLASRNFNITVLAEELIFRYLPDELSDRKRIYD
  EEMSELSNLTRDVPIFVCAMAFPTVPCPLHVFEPRYRLMIRRCMETGTKRFGMCLSAEHAGLSEYGCMLEIKDVR
  TFPDGSSVVDAIGISRFRVLSHRHRDGYNTADIEYLEDEKVEGPEYEELAALHDSVHQQSVSWFASLQDRMKEQI
  LSHFGVMPDREPEPQSNPSGPAWSWWILAVLPLERKAQLAILGMTSLKERLLAIRRILVIITRKMNSRQELANAR
  ERNN

• Structural information:
  • Protein Domains: (535..73-)
    (/note="Lon-N-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01123"-)
  • Interpro: IPR003111  IPR015947  IPR013026  IPR011990  IPR019734   IPR001841  IPR013083  IPR017907  
  • Prosite: PS51787 PS50293 PS00518 PS50089
  • STRING: ENSP00000377086
• Other Databases: GeneCards:  LONRF2  Malacards:  LONRF2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046872	metal ion binding	IEA	molecular function

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R