• Gene id: 1633

Gene Summary

• Gene Symbol: DCK   Gene   UCSC   Ensembl
• Gene name: deoxycytidine kinase
• Alternate names: deoxycytidine kinase, deoxyadenosine kinase, deoxyguanosine kinase, deoxynucleoside kinase,
• Gene location: 4q13.3 (70993648: 71030913)     Exons: 7     NC_000004.12
• Gene summary(Entrez): Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deox
• OMIM: 125450

Protein Summary

• Protein general information: P27707  
  • Name: Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113)
  • Length: 260  
  • Mass: 30519
• Sequence:

  MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQ
  KNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNET
  EWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNF
  DYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL

• Structural information:
  • Interpro: IPR002624  IPR031314  IPR027417  
  • CDD: cd01673
  • PDB: 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX 3IPY 3KFX 3MJR 3QEJ 3QEN 3QEO 4JLJ 4JLK 4JLM 4JLN 4KCG 4L5B 4Q18 4Q19 4Q1A 4Q1B 4Q1C 4Q1D 4Q1E 4Q1F 5MQJ 5MQL 5MQT
  • PDBsum: 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX 3IPY 3KFX 3MJR 3QEJ 3QEN 3QEO 4JLJ 4JLK 4JLM 4JLN 4KCG 4L5B 4Q18 4Q19 4Q1A 4Q1B 4Q1C 4Q1D 4Q1E 4Q1F 5MQJ 5MQL 5MQT
  • STRING: ENSP00000286648
• Other Databases: GeneCards:  DCK  Malacards:  DCK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019136	deoxynucleoside kinase activity	IBA	molecular function
GO:0004137	deoxycytidine kinase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0005739	mitochondrion	IBA	cellular component
GO:0008144	drug binding	IDA	molecular function
GO:0006220	pyrimidine nucleotide metabolic process	IDA	biological process
GO:0004137	deoxycytidine kinase activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0019136	deoxynucleoside kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006139	nucleobase-containing compound metabolic process	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0004137	deoxycytidine kinase activity	TAS	molecular function
GO:0006220	pyrimidine nucleotide metabolic process	TAS	biological process
GO:0004138	deoxyguanosine kinase activity	IEA	molecular function
GO:0004137	deoxycytidine kinase activity	IEA	molecular function
GO:0004136	deoxyadenosine kinase activity	IEA	molecular function
GO:0043097	pyrimidine nucleoside salvage	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043101	purine-containing compound salvage	TAS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEA	biological process
GO:0006170	dAMP biosynthetic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq