• Gene id: 162333

Gene Summary

• Gene Symbol: MARCHF10   Gene   UCSC   Ensembl
• Aliases: MARCH-X, MARCH10, RNF190
• Gene name: membrane associated ring-CH-type finger 10
• Alternate names: probable E3 ubiquitin-protein ligase MARCH10, RING-type E3 ubiquitin transferase MARCH10, membrane associated ring finger 10, membrane-associated RING finger protein 10, membrane-associated RING-CH protein X, membrane-associated ring finger (C3HC4) 10, E3 ubiq,
• Gene location: 17q23.2 (62808345: 62701313)     Exons: 17     NC_000001.11
• Gene summary(Entrez): MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (
• OMIM: 613337

Diseases

Associated diseases	References
Involved in spermiogenesis by regulating the formation and maintenance of the flagella in developing spermatids	MIK: 21937444
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Involved in spermiogenesis by regulating the formation and maintenance of the flagella in developing spermatids	MIK: 21937444
Non obstructive azoospermia	MIK: 24012201
Non obstructive azoospermia	MIK: 23869807
Sertoli cell only syndrome	MIK: 23869807

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21937444	Involved in spermiogenesis by regulating the formation and maintenance of the flagella in developing spermatids				Male infertility
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)