• Gene id: 161931

Gene Summary

• Gene Symbol: ADAD2   Gene   UCSC   Ensembl
• Aliases: TENRL
• Gene name: adenosine deaminase domain containing 2
• Alternate names: adenosine deaminase domain-containing protein 2,
• Gene location: 16q24.1 (84191156: 84197165)     Exons: 13     NC_000016.10

Protein Summary

• Protein general information: Q8NCV1  
  • Name: Adenosine deaminase domain containing protein 2 (Testis nuclear RNA binding protein like)
  • Length: 583  
  • Mass: 61755
• Sequence:

  MASASQGADDDGSRRKPRLAASLQISPQPRPWRPLPAQAQSAWGPAPAPATYRAEGGWPQVSVLRDSGPGAGAGV
  GELGAARAWENLGEQMGKAPRVPVPPAGLSLPLKDPPASQAVSLLTEYAASLGIFLLFREDQPPGPCFPFSVSAE
  LDGVVCPAGTANSKTEAKQQAALSALCYIRSQLENPESPQTSSRPPLAPLSVENILTHEQRCAALVSAGFDLLLD
  ERSPYWACKGTVAGVILEREIPRARGHVKEIYKLVALGTGSSCCAGWLEFSGQQLHDCHGLVIARRALLRFLFRQ
  LLLATQGGPKGKEQSVLAPQPGPGPPFTLKPRVFLHLYISNTPKGAARDIYLPPTSEGGLPHSPPMRLQAHVLGQ
  LKPVCYVAPSLCDTHVGCLSASDKLARWAVLGLGGALLAHLVSPLYSTSLILADSCHDPPTLSRAIHTRPCLDSV
  LGPCLPPPYVRTALHLFAGPPVAPSEPTPDTCRGLSLNWSLGDPGIEVVDVATGRVKANAALGPPSRLCKASFLR
  AFHQAARAVGKPYLLALKTYEAAKAGPYQEARRQLSLLLDQQGLGAWPSKPLVGKFRN

• Structural information:
  • Protein Domains: (115..18-)
    (/note="DRBM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00266-)
    (261..58-)
    I (/note="A-to)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00240"-)
  • Interpro: IPR002466  IPR014720  
  • Prosite: PS50141 PS50137
  • CDD: cd00048
  • STRING: ENSP00000268624
• Other Databases: GeneCards:  ADAD2  Malacards:  ADAD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008251	tRNA-specific adenosine deaminase activity	IBA	molecular function
GO:0006396	RNA processing	IBA	biological process
GO:0006382	adenosine to inosine editing	IBA	biological process
GO:0005730	nucleolus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0003726	double-stranded RNA adenosine deaminase activity	IBA	molecular function
GO:0003725	double-stranded RNA binding	IBA	molecular function
GO:0004000	adenosine deaminase activity	IEA	molecular function
GO:0006396	RNA processing	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881