• Gene id: 161823

Gene Summary

• Gene Symbol: ADAL   Gene   UCSC   Ensembl
• Aliases: HsMAPDA
• Gene name: adenosine deaminase like
• Alternate names: adenosine deaminase-like protein, N6-mAMP deaminase, N6-methyl-AMP aminohydrolase,
• Gene location: 15q15.3 (43330340: 43354568)     Exons: 1     NC_000015.10

Protein Summary

• Protein general information: Q6DHV7  
  • Name: Adenosine deaminase like protein (EC 3.5.4. ) (Adenosine deaminase like protein isoform 1) (N6 mAMP deaminase) (HsMAPDA) (N6 methyl AMP aminohydrolase)
  • Length: 355  
  • Mass: 40264
• Sequence:

  MIEAEEQQPCKTDFYSELPKVELHAHLNGSISSHTMKKLIAQKPDLKIHDQMTVIDKGKKRTLEECFQMFQTIHQ
  LTSSPEDILMVTKDVIKEFADDGVKYLELRSTPRRENATGMTKKTYVESILEGIKQSKQENLDIDVRYLIAVDRR
  GGPLVAKETVKLAEEFFLSTEGTVLGLDLSGDPTVGQAKDFLEPLLEAKKAGLKLALHLSEIPNQKKETQILLDL
  LPDRIGHGTFLNSGEGGSLDLVDFVRQHRIPLELCLTSNVKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFAT
  HLSQEYQLAAETFNLTQSQVWDLSYESINYIFASDSTRSELRKKWNHLKPRVLHI

• Structural information:
  • Interpro: IPR001365  IPR032466  
  • STRING: ENSP00000398744
• Other Databases: GeneCards:  ADAL  Malacards:  ADAL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006154	adenosine catabolic process	IBA	biological process
GO:0046103	inosine biosynthetic process	IBA	biological process
GO:0004000	adenosine deaminase activity	IBA	molecular function
GO:0019239	deaminase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0009117	nucleotide metabolic process	IEA	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0017144	drug metabolic process	TAS	biological process
GO:0043101	purine-containing compound salvage	TAS	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)