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Gene id 1606
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol DGKA   Gene   UCSC   Ensembl
Aliases DAGK, DAGK1, DGK-alpha
Gene name diacylglycerol kinase alpha
Alternate names diacylglycerol kinase alpha, 80 kDa diacylglycerol kinase, DAG kinase alpha, diacylglycerol kinase, alpha 80kDa, diglyceride kinase alpha,
Gene location 12q13.2 (55931090: 55954022)     Exons: 33     NC_000012.12
Gene summary(Entrez) The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important rol
OMIM 125855

Protein Summary

Protein general information P23743  

Name: Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK alpha)

Length: 735  Mass: 82630

Tissue specificity: Lymphocytes and oligodendroglial cells.

Sequence MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALF
QSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLD
WDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESS
IGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTH
PLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL
PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYF
SIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNA
GRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
Structural information
Protein Domains
(110..14-)
(/note="EF-hand-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
(155..19-)
(/note="EF-hand-2)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
(372..50-)
(/note="DAGKc-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU007-)
Interpro:  IPR017438  IPR029477  IPR037607  IPR038199  IPR000756  
IPR001206  IPR011992  IPR018247  IPR002048  IPR016064  IPR002219  
Prosite:   PS50146 PS00018 PS50222 PS00479 PS50081
CDD:   cd00029 cd00051

PDB:  
1TUZ 6IIE
PDBsum:   1TUZ 6IIE
MINT:  
STRING:   ENSP00000328405
Other Databases GeneCards:  DGKA  Malacards:  DGKA

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0004143 diacylglycerol kinase act
ivity
IBA molecular function
GO:0046834 lipid phosphorylation
IBA biological process
GO:0046486 glycerolipid metabolic pr
ocess
IBA biological process
GO:0046339 diacylglycerol metabolic
process
IBA biological process
GO:0035556 intracellular signal tran
sduction
IBA biological process
GO:0005886 plasma membrane
IBA cellular component
GO:0006654 phosphatidic acid biosynt
hetic process
IDA biological process
GO:0004143 diacylglycerol kinase act
ivity
IDA molecular function
GO:0046339 diacylglycerol metabolic
process
IDA biological process
GO:0046834 lipid phosphorylation
IDA biological process
GO:0005829 cytosol
IDA cellular component
GO:0006654 phosphatidic acid biosynt
hetic process
IDA biological process
GO:0004143 diacylglycerol kinase act
ivity
IDA molecular function
GO:0046339 diacylglycerol metabolic
process
IDA biological process
GO:0046834 lipid phosphorylation
IDA biological process
GO:0003951 NAD+ kinase activity
IEA molecular function
GO:0004143 diacylglycerol kinase act
ivity
IEA molecular function
GO:0005509 calcium ion binding
IEA molecular function
GO:0007165 signal transduction
IEA biological process
GO:0007205 protein kinase C-activati
ng G protein-coupled rece
ptor signaling pathway
IEA biological process
GO:0016301 kinase activity
IEA molecular function
GO:0035556 intracellular signal tran
sduction
IEA biological process
GO:0046872 metal ion binding
IEA molecular function
GO:0016740 transferase activity
IEA molecular function
GO:0016301 kinase activity
IEA molecular function
GO:0016310 phosphorylation
IEA biological process
GO:0006629 lipid metabolic process
IEA biological process
GO:0000166 nucleotide binding
IEA molecular function
GO:0005524 ATP binding
IEA molecular function
GO:0005737 cytoplasm
IEA cellular component
GO:0035556 intracellular signal tran
sduction
TAS biological process
GO:0004143 diacylglycerol kinase act
ivity
IEA molecular function
GO:0005886 plasma membrane
TAS cellular component
GO:0030168 platelet activation
TAS biological process
GO:0004143 diacylglycerol kinase act
ivity
IEA molecular function
GO:0005829 cytosol
IEA cellular component
GO:0005543 phospholipid binding
IEA molecular function
GO:0005886 plasma membrane
IEA cellular component
GO:0008289 lipid binding
IDA molecular function
GO:0004143 diacylglycerol kinase act
ivity
IDA molecular function
GO:0016301 kinase activity
IDA molecular function
GO:0004143 diacylglycerol kinase act
ivity
IDA molecular function
GO:0006654 phosphatidic acid biosynt
hetic process
IDA biological process
GO:0046834 lipid phosphorylation
IDA biological process
GO:0046339 diacylglycerol metabolic
process
IDA biological process
GO:0046486 glycerolipid metabolic pr
ocess
IDA biological process
GO:0046834 lipid phosphorylation
IDA biological process
GO:0005829 cytosol
IEA cellular component
GO:0046486 glycerolipid metabolic pr
ocess
IEA biological process
GO:0016020 membrane
HDA cellular component

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa04072Phospholipase D signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa00564Glycerophospholipid metabolism
hsa05231Choline metabolism in cancer
hsa00561Glycerolipid metabolism
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract