• Gene id: 160364

Gene Summary

• Gene Symbol: CLEC12A   Gene   UCSC   Ensembl
• Aliases: CD371, CLL-1, CLL1, DCAL-2, MICL
• Gene name: C-type lectin domain family 12 member A
• Alternate names: C-type lectin domain family 12 member A, C-type lectin protein CLL-1, C-type lectin-like molecule-1, dendritic cell-associated lectin 2, myeloid inhibitory C-type lectin-like receptor,
• Gene location: 12p13.31 (9951267: 9995208)     Exons: 61     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles i
• OMIM: 612088

Protein Summary

• Protein general information: Q5QGZ9  
  • Name: C type lectin domain family 12 member A (C type lectin like molecule 1) (CLL 1) (Dendritic cell associated lectin 2) (DCAL 2) (Myeloid inhibitory C type lectin like receptor) (MICL) (CD antigen CD371)
  • Length: 265  
  • Mass: 30762
  • Tissue specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in pe
• Sequence:

  MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVLASMFHVTLKIEMKKM
  NKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDD
  VQTWQESKMACAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNM
  YCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA

• Structural information:
  • Protein Domains: (140..24-)
    (/note="C-type-lectin)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"-)
  • Interpro: IPR001304  IPR016186  IPR016187  IPR033992  
  • Prosite: PS50041
  • CDD: cd03593
  • STRING: ENSP00000347916
• Other Databases: GeneCards:  CLEC12A  Malacards:  CLEC12A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0035579	specific granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0070821	tertiary granule membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)