• Gene id: 158135

Gene Summary

• Gene Symbol: TTLL11   Gene   UCSC   Ensembl
• Aliases: C9orf20, bA244O19.1
• Gene name: tubulin tyrosine ligase like 11
• Alternate names: tubulin polyglutamylase TTLL11, tubulin tyrosine ligase like11, tubulin tyrosine ligase-like family, member 11, tubulin--tyrosine ligase-like protein 11,
• Gene location: 9q33.2 (122093605: 121815673)     Exons: 14     NC_000009.12
• OMIM: 0

Protein Summary

• Protein general information: Q8NHH1  
  • Name: Tubulin polyglutamylase TTLL11 (EC 6. . . ) (Tubulin tyrosine ligase like protein 11)
  • Length: 800  
  • Mass: 87612
• Sequence:

  MAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAAVNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAA
  AAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVDAGAAGEPECKAGEEQP
  KVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSK
  ARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPE
  EYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRLAGTLQSRPAVVQEYI
  CKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPTPKNLHRIFMHLTNYSLNIHSGNFIHSDSA
  STGSKRTFSSILCRLSSKGVDIKKVWSDIISVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNL
  KPILLEVNANPSMRIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDALD
  GELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSS
  SLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRL
  VCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPRTSCANKLSHPRHTLS

• Structural information:
  • Protein Domains: (218..57-)
    (/note="TTL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00568"-)
  • Interpro: IPR013815  IPR004344  
  • Prosite: PS51221
  • STRING: ENSP00000321346
• Other Databases: GeneCards:  TTLL11  Malacards:  TTLL11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070740	tubulin-glutamic acid ligase activity	IBA	molecular function
GO:0018095	protein polyglutamylation	IBA	biological process
GO:0015631	tubulin binding	IBA	molecular function
GO:0005929	cilium	IBA	cellular component
GO:0000226	microtubule cytoskeleton organization	IBA	biological process
GO:0006464	cellular protein modification process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005929	cilium	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016874	ligase activity	IEA	molecular function
GO:0005874	microtubule	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0018095	protein polyglutamylation	TAS	biological process
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0036064	ciliary basal body	IEA	cellular component
GO:0051013	microtubule severing	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq