• Gene id: 157855

Gene Summary

• Gene Symbol: KCNU1   Gene   UCSC   Ensembl
• Aliases: KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3
• Gene name: potassium calcium-activated channel subfamily U member 1
• Alternate names: potassium channel subfamily U member 1, Calcium-activated potassium channel subunit alpha-3, Calcium-activated potassium channel, subfamily M subunit alpha-3, Slowpoke homolog 3, potassium channel, subfamily U, member 1,
• Gene location: 8p11.23 (36784323: 36936124)     Exons: 30     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium
• OMIM: 615215

KEGG pathways

Pathway id	Pathway name
hsa04022	cGMP-PKG signaling pathway
hsa04911	Insulin secretion
hsa04270	Vascular smooth muscle contraction
hsa04022	cGMP-PKG signaling pathway
hsa04911	Insulin secretion
hsa04270	Vascular smooth muscle contraction

Diseases

Associated diseases	References
It is the principal potassium channel responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the Acrosome reaction	MIK: 20138882
It is the principal potassium channel responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the Acrosome reaction	MIK: 20138882
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
20138882	It is the principal potassium channel responsible for capacitation-induced hyperpolarization, and membrane hyperpolarization is crucial to the Acrosome reaction				Male infertility
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray