• Gene id: 157807

Gene Summary

• Gene Symbol: CLVS1   Gene   UCSC   Ensembl
• Aliases: C6orf212L, CRALBPL, RLBP1L1
• Gene name: clavesin 1
• Alternate names: clavesin-1, clathrin vesicle-associated Sec14 protein 1, retinaldehyde-binding protein 1-like 1,
• Gene location: 8q12.2-q12.3 (60964832: 61501628)     Exons: 11     NC_000008.11
• OMIM: 602240

Protein Summary

• Protein general information: Q8IUQ0  
  • Name: Clavesin 1 (Cellular retinaldehyde binding protein like) (Retinaldehyde binding protein 1 like 1) (clathrin vesicle associated Sec14 protein 1)
  • Length: 354  
  • Mass: 40788
  • Tissue specificity: Expressed mainly in the brain. {ECO
• Sequence:

  MGPVSLLPKYQKLNTWNGDLAKMTHLQAGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAF
  ILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQ
  SRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQ
  PWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTH
  TSYNAMHVKHTSSNLERECSPKLMKRSQSVVEAGTLKHEEKGENENTQPLLALD

• Structural information:
  • Protein Domains: (118..27-)
    (/note="CRAL-TRIO-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00056"-)
  • Interpro: IPR028634  IPR001251  IPR036865  IPR011074  IPR036273  
  • Prosite: PS50191
  • CDD: cd00170
  • STRING: ENSP00000428402
• Other Databases: GeneCards:  CLVS1  Malacards:  CLVS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005768	endosome	IBA	cellular component
GO:0005802	trans-Golgi network	IBA	cellular component
GO:0007040	lysosome organization	IBA	biological process
GO:1902936	phosphatidylinositol bisphosphate binding	IBA	molecular function
GO:0030136	clathrin-coated vesicle	IBA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005802	trans-Golgi network	IEA	cellular component
GO:0007040	lysosome organization	IEA	biological process
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	IEA	molecular function
GO:0030136	clathrin-coated vesicle	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0032588	trans-Golgi network membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0031901	early endosome membrane	IEA	cellular component
GO:0030136	clathrin-coated vesicle	IEA	cellular component
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	IDA	molecular function
GO:0005768	endosome	IDA	cellular component
GO:0030136	clathrin-coated vesicle	ISS	cellular component
GO:0007040	lysosome organization	ISS	biological process
GO:0005802	trans-Golgi network	ISS	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881