• Gene id: 157313

Gene Summary

• Gene Symbol: CDCA2   Gene   UCSC   Ensembl
• Aliases: PPP1R81, Repo-Man
• Gene name: cell division cycle associated 2
• Alternate names: cell division cycle-associated protein 2, protein phosphatase 1, regulatory subunit 81, recruits PP1 onto mitotic chromatin at anaphase protein,
• Gene location: 8p21.2 (25458556: 25511307)     Exons: 18     NC_000008.11
• Gene summary(Entrez): This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope r
• OMIM: 618785

Protein Summary

• Protein general information: Q69YH5  
  • Name: Cell division cycle associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo Man)
  • Length: 1023  
  • Mass: 112676
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRN
  SAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQS
  AFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQ
  IFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS
  SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAED
  EENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDD
  KGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLL
  NTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP
  EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSD
  EDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLC
  QFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCR
  DRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL
  ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRR
  KSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ

• Structural information:
  • Protein Domains: (389..44-)
    (/note="PP1-binding"-)
  • Interpro: IPR033064  IPR029334  
  • PDB: 5INB 5IOH 5SW9
  • PDBsum: 5INB 5IOH 5SW9
  • STRING: ENSP00000328228
• Other Databases: GeneCards:  CDCA2  Malacards:  CDCA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051301	cell division	IEA	biological process
GO:0035307	positive regulation of protein dephosphorylation	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005694	chromosome	IDA	cellular component
GO:0035307	positive regulation of protein dephosphorylation	IMP	biological process
GO:0007059	chromosome segregation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq