• Gene id: 155971

Gene Summary

• Gene Symbol: env   Gene   UCSC   Ensembl
• Aliases: HIV1gp8
• Alternate names: gp160, envelope glycoprotein, Envelope surface glycoprotein gp160, precursor,
• OMIM: 0

Protein Summary

• Protein general information: P04578  
  • Name: Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
  • Length: 856  
  • Mass: 97,213
• Sequence:

  MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACV
  PTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIME
  KGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAI
  LKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPN
  NNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHS
  FNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRCSSNIT
  GLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGA
  AGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSG
  KLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNI
  TNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVN
  GSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEG
  TDRVIEVVQGACRAIRHIPRRIRQGLERILL

• Structural information:
  • Interpro: IPR036377  IPR037527  IPR000328  IPR000777  
  • CDD: cd09909
  • PDB: 1AIK 1DF4 1DF5 1DLB 1FAV 1G9M 1GC1 1GZL 1K33 1K34 1MZI 1OPN 1OPT 1OPW 1RZJ 2CMR 2ME1 2MG1 2MG2 2MG3 2NY7 2PV6 2XRA 3D0V 3DNL 3DNN 3DNO 3DRO 3IDX 3IDY 3J70 3MNZ 3TYG 3VIE 4JPJ 4JPK 4YDV 4ZTO 5BN0 5C0R 5C0S 5CIL 5CIN 5CMU 5CMZ 5CN0 5DD0 5GHW 5H0N 5HFL 5HM1
  • PDBsum: 1AIK 1DF4 1DF5 1DLB 1FAV 1G9M 1GC1 1GZL 1K33 1K34 1MZI 1OPN 1OPT 1OPW 1RZJ 2CMR 2ME1 2MG1 2MG2 2MG3 2NY7 2PV6 2XRA 3D0V 3DNL 3DNN 3DNO 3DRO 3IDX 3IDY 3J70 3MNZ 3TYG 3VIE 4JPJ 4JPK 4YDV 4ZTO 5BN0 5C0R 5C0S 5CIL 5CIN 5CMU 5CMZ 5CN0 5DD0 5GHW 5H0N 5HFL 5HM1
  • DIP: 58525
• Other Databases: GeneCards:  env  Malacards:  env

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	biological process
GO:0005198	structural molecule activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0019012	virion	IEA	cellular component
GO:0019012	virion	IDA	cellular component
GO:0019012	virion	IDA	cellular component
GO:0019031	viral envelope	IEA	cellular component
GO:0019031	viral envelope	IEA	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019058	viral life cycle	TAS	biological process
GO:0019062	virion attachment to host cell	IEA	biological process
GO:0019062	virion attachment to host cell	IDA	biological process
GO:0019064	fusion of virus membrane with host plasma membrane	IDA	biological process
GO:0019064	fusion of virus membrane with host plasma membrane	TAS	biological process
GO:0019068	virion assembly	TAS	biological process
GO:0019082	viral protein processing	IDA	biological process
GO:0019082	viral protein processing	TAS	biological process
GO:0020002	host cell plasma membrane	IEA	cellular component
GO:0020002	host cell plasma membrane	IEA	cellular component
GO:0020002	host cell plasma membrane	IDA	cellular component
GO:0030260	entry into host cell	TAS	biological process
GO:0030683	evasion or tolerance by virus of host immune response	IEA	biological process
GO:0033644	host cell membrane	IEA	cellular component
GO:0039654	fusion of virus membrane with host endosome membrane	IEA	biological process
GO:0039663	membrane fusion involved in viral entry into host cell	IEA	biological process
GO:0044174	host cell endosome	IEA	cellular component
GO:0044175	host cell endosome membrane	IEA	cellular component
GO:0046718	viral entry into host cell	IEA	biological process
GO:0055036	virion membrane	IEA	cellular component
GO:0075509	endocytosis involved in viral entry into host cell	IEA	biological process
GO:0075512	clathrin-dependent endocytosis of virus by host cell	IEA	biological process
GO:0075512	clathrin-dependent endocytosis of virus by host cell	IDA	biological process
GO:0075512	clathrin-dependent endocytosis of virus by host cell	IDA	biological process
GO:0090527	actin filament reorganization	IDA	biological process
GO:1903905	positive regulation of establishment of T cell polarity	IDA	biological process
GO:1903908	positive regulation of plasma membrane raft polarization	IDA	biological process
GO:1903911	positive regulation of receptor clustering	IDA	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019012	virion	IDA	cellular component
GO:0019012	virion	IDA	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019058	viral life cycle	TAS	biological process
GO:0019062	virion attachment to host cell	IDA	biological process
GO:0019064	fusion of virus membrane with host plasma membrane	IDA	biological process
GO:0019064	fusion of virus membrane with host plasma membrane	TAS	biological process
GO:0019068	virion assembly	TAS	biological process
GO:0019082	viral protein processing	IDA	biological process
GO:0019082	viral protein processing	TAS	biological process
GO:0020002	host cell plasma membrane	IDA	cellular component
GO:0030260	entry into host cell	TAS	biological process
GO:0075512	clathrin-dependent endocytosis of virus by host cell	IDA	biological process
GO:0075512	clathrin-dependent endocytosis of virus by host cell	IDA	biological process
GO:0090527	actin filament reorganization	IDA	biological process
GO:1903905	positive regulation of establishment of T cell polarity	IDA	biological process
GO:1903908	positive regulation of plasma membrane raft polarization	IDA	biological process
GO:1903911	positive regulation of receptor clustering	IDA	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0030260	entry into host cell	TAS	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0019082	viral protein processing	TAS	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019064	fusion of virus membrane with host plasma membrane	TAS	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019058	viral life cycle	TAS	biological process
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0019031	viral envelope	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019068	virion assembly	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0000139	Golgi membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component

Diseases

Associated diseases	References
Pelvic endometriosis	INFBASE: 26871558
Female infertility	INFBASE: 26871558

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
20369545	Asthenozoospermia			6 seminal plasma samples were collected by Percoll respectively from healthy fertile and asthenozoospermia volunteers	Male infertility	annexin VI isoform 2 isoform 1 of interleukin-6 receptor subunit beta precursor Mr 400 000 protein cytosolic dynein heavy chain alpha-actinin-4 receptor-type tyrosine-protein phosphatase eta precursor vitamin D-binding protein precursor protein S10
20231113	Asthenozoospermia			12 (6 healthy fertile men, 6 asthenozoospermia volunteers)	Male infertility	annexin VI isoform 2 isoform 1 of interleukin-6 receptor subunit beta precursor Mr 400 000 protein cytosolic dynein heavy chain alpha-actinin-4 receptor-type tyrosine-protein phosphatase eta precursor vitamin D-binding protein precursor protein S10