• Gene id: 1559

Gene Summary

• Gene Symbol: CYP2C9   Gene   UCSC   Ensembl
• Aliases: CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
• Gene name: cytochrome P450 family 2 subfamily C member 9
• Alternate names: cytochrome P450 2C9, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P-450MP, cytochrome P450 PB-1, cytochrome P450, family 2, subfamily C, polypeptide 9, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase,
• Gene location: 10q23.33 (94938657: 94990090)     Exons: 9     NC_000010.11
• Gene summary(Entrez): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local
• OMIM: 138700

Protein Summary

• Protein general information: P11712  
  • Name: Cytochrome P450 2C9 (EC 1.14.14.1) ((R) limonene 6 monooxygenase) (EC 1.14.14.53) ((S) limonene 6 monooxygenase) (EC 1.14.14.51) ((S) limonene 7 monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25 hydroxylase) (Cytochrome P 450MP) (Cytochrome P450 MP
  • Length: 490  
  • Mass: 55628
• Sequence:

  MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIV
  VLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAR
  CLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDY
  FPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
  TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK
  FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLT
  SILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV

• Structural information:
  • Interpro: IPR001128  IPR017972  IPR002401  IPR036396  
  • Prosite: PS00086
  • PDB: 1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI
  • PDBsum: 1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI
  • STRING: ENSP00000260682
• Other Databases: GeneCards:  CYP2C9  Malacards:  CYP2C9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0008395	steroid hydroxylase activity	IBA	molecular function
GO:0019373	epoxygenase P450 pathway	IBA	biological process
GO:0042738	exogenous drug catabolic process	IBA	biological process
GO:0006082	organic acid metabolic process	IBA	biological process
GO:0006805	xenobiotic metabolic process	IBA	biological process
GO:0008392	arachidonic acid epoxygenase activity	IBA	molecular function
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA	molecular function
GO:0020037	heme binding	IBA	molecular function
GO:0043231	intracellular membrane-bounded organelle	IBA	cellular component
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0004497	monooxygenase activity	IDA	molecular function
GO:0008392	arachidonic acid epoxygenase activity	IDA	molecular function
GO:0046456	icosanoid biosynthetic process	IDA	biological process
GO:0019373	epoxygenase P450 pathway	IDA	biological process
GO:0008210	estrogen metabolic process	IDA	biological process
GO:0005506	iron ion binding	IEA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0043231	intracellular membrane-bounded organelle	IEA	cellular component
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0008202	steroid metabolic process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0018676	(S)-limonene 7-monooxygenase activity	IEA	molecular function
GO:0070330	aromatase activity	IEA	molecular function
GO:0052741	(R)-limonene 6-monooxygenase activity	IEA	molecular function
GO:0018675	(S)-limonene 6-monooxygenase activity	IEA	molecular function
GO:0019373	epoxygenase P450 pathway	TAS	biological process
GO:0097267	omega-hydroxylase P450 pathway	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0006805	xenobiotic metabolic process	TAS	biological process
GO:0042759	long-chain fatty acid biosynthetic process	TAS	biological process
GO:0004497	monooxygenase activity	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0034875	caffeine oxidase activity	IDA	molecular function
GO:0008395	steroid hydroxylase activity	IMP	molecular function
GO:0017144	drug metabolic process	IDA	biological process
GO:0017144	drug metabolic process	IDA	biological process
GO:0032787	monocarboxylic acid metabolic process	IDA	biological process
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0016098	monoterpenoid metabolic process	IDA	biological process
GO:0019627	urea metabolic process	IDA	biological process
GO:0042738	exogenous drug catabolic process	IDA	biological process
GO:0043603	cellular amide metabolic process	IDA	biological process
GO:0070989	oxidative demethylation	IDA	biological process
GO:0008202	steroid metabolic process	IMP	biological process
GO:0042737	drug catabolic process	IMP	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0031090	organelle membrane	IEA	cellular component
GO:0019369	arachidonic acid metabolic process	IEA	biological process
GO:0008203	cholesterol metabolic process	IEA	biological process
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	TAS	cellular component
GO:0017144	drug metabolic process	IMP	biological process
GO:0043231	intracellular membrane-bounded organelle	TAS	cellular component
GO:0004497	monooxygenase activity	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04726	Serotonergic synapse
hsa05204	Chemical carcinogenesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450
hsa00830	Retinol metabolism
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism

Diseases

Associated diseases	References
Coumarin resistance	KEGG:H01205
Hypertension	PMID:19669737
urinary bladder cancer	PMID:16985032
Hyperglycemia	PMID:17597710
diabetes mellitus	PMID:16788382
diabetes mellitus	PMID:16303885
type 2 diabetes mellitus	PMID:16325295
hypoglycemia	PMID:15963101
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray