• Gene id: 1557

Gene Summary

• Gene Symbol: CYP2C19   Gene   UCSC   Ensembl
• Aliases: CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
• Gene name: cytochrome P450 family 2 subfamily C member 19
• Alternate names: cytochrome P450 2C19, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, S-mephenytoin 4-hydroxylase, cytochrome P-450 II C, cytochrome P450, family 2, subfamily C, polypeptide 19, cytochrome P450, subfamily IIC (mephenytoi,
• Gene location: 10q23.33 (94762680: 94855546)     Exons: 16     NC_000010.11
• Gene summary(Entrez): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local
• OMIM: 124020

SNPs

rs11568732

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.94761817T>C
NC_000010.11   g.94761817T>G
NC_000010.10   g.96521574T>C
NC_000010.10   g.96521574T>G
NG_008384.3   g.4137T>C
NG_008384.3   g.4137T>G
NG_055436.1   g.1177T>C
NG_055436.1   g.1177T>G|SEQ=[T/C/G]|GENE=CYP2C19

rs4986894

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.94762608T>C
NC_000010.10   g.96522365T>C
NG_008384.3   g.4928T>C
NG_055436.1   g.1968T>C|SEQ=[T/C]|GENE=CYP2C19

Protein Summary

• Protein general information: P33261  
  • Name: Cytochrome P450 2C19 (EC 1.14.14.1) ((R) limonene 6 monooxygenase) (EC 1.14.14.53) ((S) limonene 6 monooxygenase) (EC 1.14.14.51) ((S) limonene 7 monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450 11A) (Cytochrome P450 254C) (Fenbendazo
  • Length: 490  
  • Mass: 55931
• Sequence:

  MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMV
  VLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAR
  CLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDY
  FPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
  TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK
  FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT
  FILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV

• Structural information:
  • Interpro: IPR001128  IPR017972  IPR002401  IPR036396  
  • Prosite: PS00086
  • PDB: 4GQS
  • PDBsum: 4GQS
  • STRING: ENSP00000360372
• Other Databases: GeneCards:  CYP2C19  Malacards:  CYP2C19

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006082	organic acid metabolic process	IBA	biological process
GO:0006805	xenobiotic metabolic process	IBA	biological process
GO:0008392	arachidonic acid epoxygenase activity	IBA	molecular function
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA	molecular function
GO:0020037	heme binding	IBA	molecular function
GO:0043231	intracellular membrane-bounded organelle	IBA	cellular component
GO:0055114	oxidation-reduction process	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0008395	steroid hydroxylase activity	IBA	molecular function
GO:0019373	epoxygenase P450 pathway	IBA	biological process
GO:0042738	exogenous drug catabolic process	IBA	biological process
GO:0020037	heme binding	IDA	molecular function
GO:0005506	iron ion binding	IEA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0043231	intracellular membrane-bounded organelle	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0004497	monooxygenase activity	TAS	molecular function
GO:0019825	oxygen binding	TAS	molecular function
GO:0043231	intracellular membrane-bounded organelle	TAS	cellular component
GO:0070330	aromatase activity	IEA	molecular function
GO:0018675	(S)-limonene 6-monooxygenase activity	IEA	molecular function
GO:0052741	(R)-limonene 6-monooxygenase activity	IEA	molecular function
GO:0018676	(S)-limonene 7-monooxygenase activity	IEA	molecular function
GO:0019373	epoxygenase P450 pathway	TAS	biological process
GO:0097267	omega-hydroxylase P450 pathway	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0006805	xenobiotic metabolic process	TAS	biological process
GO:0004497	monooxygenase activity	IDA	molecular function
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0016491	oxidoreductase activity	IDA	molecular function
GO:0008395	steroid hydroxylase activity	IMP	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0017144	drug metabolic process	IDA	biological process
GO:0017144	drug metabolic process	IDA	biological process
GO:0046483	heterocycle metabolic process	IDA	biological process
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0016098	monoterpenoid metabolic process	IDA	biological process
GO:0042738	exogenous drug catabolic process	IDA	biological process
GO:0008202	steroid metabolic process	IMP	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0031090	organelle membrane	IEA	cellular component
GO:0006631	fatty acid metabolic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04726	Serotonergic synapse
hsa05204	Chemical carcinogenesis
hsa00982	Drug metabolism - cytochrome P450
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism

Diseases

Associated diseases	References
Poor drug metabolism	KEGG:H01171
Sickle cell anemia	PMID:20831548
multiple myeloma	PMID:17666363
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)