• Gene id: 154661

Gene Summary

• Gene Symbol: RUNDC3B   Gene   UCSC   Ensembl
• Aliases: RPIB9, RPIP9
• Gene name: RUN domain containing 3B
• Alternate names: RUN domain-containing protein 3B, RPIP-9, Rap2 binding protein 9, Rap2-interacting protein 9, rap2-binding protein 9,
• Gene location: 7q21.12 (87627655: 87832295)     Exons: 15     NC_000007.14
• OMIM: 617295

Protein Summary

• Protein general information: Q96NL0  
  • Name: RUN domain containing protein 3B (Rap2 binding protein 9) (Rap2 interacting protein 9) (RPIP 9)
  • Length: 473  
  • Mass: 52813
  • Tissue specificity: Isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine and prostate. Isoform 1 is expressed in the brain, testis and adrenal gland. It is activated in tumorigenic breast cancer cell lin
• Sequence:

  MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILS
  HRLKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVAL
  MEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYI
  QSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSES
  VSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLL
  YRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKSLT
  SLKSNDYLASPTTEMTSPGLTPS

• Structural information:
  • Protein Domains: (57..20-)
    (/note="RUN-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00178"-)
  • Interpro: IPR004012  IPR037213  
  • Prosite: PS50826
  • STRING: ENSP00000337732
• Other Databases: GeneCards:  RUNDC3B  Malacards:  RUNDC3B

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)