• Gene id: 154

Gene Summary

• Gene Symbol: ADRB2   Gene   UCSC   Ensembl
• Aliases: ADRB2R, ADRBR, B2AR, BAR, BETA2AR
• Gene name: adrenoceptor beta 2
• Alternate names: beta-2 adrenergic receptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor,
• Gene location: 5q32 (148826610: 148828622)     Exons: 1     NC_000005.10
• Gene summary(Entrez): This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel compl
• OMIM: 109690

SNPs

rs864309485

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30846888A>C
NC_000008.10   g.30704404A>C
NG_053141.1   g.71125T>G
NM_001350162.2   c.3279T>G
NM_001350162.1   c.3279T>G
XM_006716369.4   c.3279T>G
XM_011544593.3   c.2970T>G
XM_011544590.3   c.3279T>G
XM_011544589.3   c.3279T>G
XM_011544591.3   c.3279T>

rs13206743

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.52152310T>C
NC_000006.11   g.52017108T>C|SEQ=[T/C]|GENE=LINCMD1

rs1056836

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000002.12   g.38071060G>C
NC_000002.11   g.38298203C>G
NG_008386.2   g.10042C>G
NM_000104.3   c.1294C>G
NP_000095.2   p.Leu432Val|SEQ=[G/C]|GENE=CYP1B1

rs323347

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30848708A>G
NC_000008.10   g.30706224A>G
NG_053141.1   g.69305T>C
NM_001350162.2   c.1459T>C
NM_001350162.1   c.1459T>C
NP_001337091.1   p.Cys487Arg|SEQ=[A/G]|GENE=TEX15

rs323346

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845915T>C
NC_000008.10   g.30703431T>C
NG_053141.1   g.72098A>G
NM_001350162.2   c.4252A>G
NM_001350162.1   c.4252A>G
NP_001337091.1   p.Ile1418Val|SEQ=[T/C]|GENE=TEX15

rs2472304

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000015.10   g.74751897G>A
NC_000015.9   g.75044238G>A
NG_008431.2   g.34356G>A
NG_061543.1   g.8053G>A|SEQ=[G/A]|GENE=CYP1A2

rs2855658

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000002.12   g.38069747T>C
NC_000002.11   g.38296890T>C
NG_008386.2   g.11355A>G
NM_000104.3   c.*975A>G|SEQ=[T/C]|GENE=CYP1B1
RMDN2   151393

rs1048943

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000015.10   g.74720644T>A
NC_000015.10   g.74720644T>C
NC_000015.10   g.74720644T>G
NC_000015.9   g.75012985T>A
NC_000015.9   g.75012985T>C
NC_000015.9   g.75012985T>G
NG_008431.2   g.3103T>A
NG_008431.2   g.3103T>C
NG_008431.2   g.3103T>G
NM_000499.4   c.1384A>T
NM_  

rs4646903

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000015.10   g.74719300A>G
NC_000015.10   g.74719300A>T
NC_000015.9   g.75011641A>G
NC_000015.9   g.75011641A>T
NG_008431.2   g.1759A>G
NG_008431.2   g.1759A>T
NG_061374.1   g.11229T>C
NG_061374.1   g.11229T>A|SEQ=[A/G/T]|GENE=CYP1A1

rs4646422

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000015.10   g.74722964C>G
NC_000015.10   g.74722964C>T
NC_000015.9   g.75015305C>G
NC_000015.9   g.75015305C>T
NG_008431.2   g.5423C>G
NG_008431.2   g.5423C>T
NM_000499.4   c.134G>C
NM_000499.4   c.134G>A
NM_000499.5   c.134G>C
NM_000499.5   c.134G>A
NM_000499.3   c.13

rs323344

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845009A>C
NC_000008.10   g.30702525A>C
NG_053141.1   g.73004T>G
NM_001350162.2   c.5158T>G
NM_001350162.1   c.5158T>G
NP_001337091.1   p.Leu1720Val|SEQ=[A/C]|GENE=TEX15

rs323345

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845086T>C
NC_000008.10   g.30702602T>C
NG_053141.1   g.72927A>G
NM_001350162.2   c.5081A>G
NM_001350162.1   c.5081A>G
NP_001337091.1   p.Asn1694Ser|SEQ=[T/C]|GENE=TEX15

Protein Summary

• Protein general information: P07550  
  • Name: Beta 2 adrenergic receptor (Beta 2 adrenoreceptor) (Beta 2 adrenoceptor)
  • Length: 413  
  • Mass: 46459
• Sequence:

  MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSL
  ACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKA
  RVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQE
  AKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
  NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENK
  LLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

• Structural information:
  • Interpro: IPR002233  IPR000332  IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • PDB: 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6MXT 6N48 6NI3 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6
  • PDBsum: 1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6MXT 6N48 6NI3 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6
  • DIP: 33948
  • STRING: ENSP00000305372
• Other Databases: GeneCards:  ADRB2  Malacards:  ADRB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001540	amyloid-beta binding	IDA	molecular function
GO:0004941	beta2-adrenergic receptor activity	NAS	molecular function
GO:1990911	response to psychosocial stress	TAS	biological process
GO:0044877	protein-containing complex binding	IPI	molecular function
GO:1904646	cellular response to amyloid-beta	IGI	biological process
GO:2000481	positive regulation of cAMP-dependent protein kinase activity	TAS	biological process
GO:2000969	positive regulation of AMPA receptor activity	IGI	biological process
GO:0016020	membrane	NAS	cellular component
GO:0010739	positive regulation of protein kinase A signaling	IGI	biological process
GO:0071902	positive regulation of protein serine/threonine kinase activity	IGI	biological process
GO:0004941	beta2-adrenergic receptor activity	IDA	molecular function
GO:0051380	norepinephrine binding	IDA	molecular function
GO:0006898	receptor-mediated endocytosis	IDA	biological process
GO:0007190	activation of adenylate cyclase activity	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0043410	positive regulation of MAPK cascade	IDA	biological process
GO:0043235	receptor complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA	biological process
GO:0004941	beta2-adrenergic receptor activity	IBA	molecular function
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0007267	cell-cell signaling	IBA	biological process
GO:0045986	negative regulation of smooth muscle contraction	IBA	biological process
GO:0051379	epinephrine binding	IBA	molecular function
GO:0051380	norepinephrine binding	IBA	molecular function
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	biological process
GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	biological process
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004935	adrenergic receptor activity	IEA	molecular function
GO:0004941	beta2-adrenergic receptor activity	IEA	molecular function
GO:0006940	regulation of smooth muscle contraction	IEA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0097746	regulation of blood vessel diameter	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0005764	lysosome	TAS	cellular component
GO:0005768	endosome	TAS	cellular component
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	TAS	biological process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	biological process
GO:0008333	endosome to lysosome transport	TAS	biological process
GO:0043235	receptor complex	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0010008	endosome membrane	TAS	cellular component
GO:0016579	protein deubiquitination	TAS	biological process
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0030665	clathrin-coated vesicle membrane	TAS	cellular component
GO:0061024	membrane organization	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1904646	cellular response to amyloid-beta	IEA	biological process
GO:0050873	brown fat cell differentiation	IEA	biological process
GO:0045986	negative regulation of smooth muscle contraction	IEA	biological process
GO:0031649	heat generation	IEA	biological process
GO:0030501	positive regulation of bone mineralization	IEA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004941	beta2-adrenergic receptor activity	IEA	molecular function
GO:0002028	regulation of sodium ion transport	IEA	biological process
GO:0002024	diet induced thermogenesis	IEA	biological process
GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	IEA	biological process
GO:0120162	positive regulation of cold-induced thermogenesis	IEA	biological process
GO:0061885	positive regulation of mini excitatory postsynaptic potential	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0045453	bone resorption	IEA	biological process
GO:0040015	negative regulation of multicellular organism growth	IEA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0010739	positive regulation of protein kinase A signaling	IEA	biological process
GO:0009409	response to cold	IEA	biological process
GO:0008179	adenylate cyclase binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA	biological process
GO:0015459	potassium channel regulator activity	IDA	molecular function
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0031398	positive regulation of protein ubiquitination	IMP	biological process
GO:0005769	early endosome	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:1901098	positive regulation of autophagosome maturation	IDA	biological process
GO:1904504	positive regulation of lipophagy	IDA	biological process
GO:0120162	positive regulation of cold-induced thermogenesis	ISS	biological process
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0071875	adrenergic receptor signaling pathway	IDA	biological process
GO:0004941	beta2-adrenergic receptor activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04024	cAMP signaling pathway
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04970	Salivary secretion
hsa04924	Renin secretion
hsa04923	Regulation of lipolysis in adipocytes

Diseases

Associated diseases	References
Polycystic ovary syndrome (PCOS)	INFBASE: 16779985
Female infertility	INFBASE: 16779985
Genetic obesity	KEGG:H02106
Asthma	KEGG:H00079
Genetic obesity	KEGG:H02106
Asthma	KEGG:H00079
open-angle glaucoma	PMID:16785856
primary open angle glaucoma	PMID:16785856
Hypertension	PMID:16041242
Pulmonary edema	PMID:20546540
Graves' disease	PMID:17143563
Cystic fibrosis	PMID:20203292
Cystic fibrosis	PMID:17502834
Urticaria	PMID:18159608
Dermatitis	PMID:16955193
Asthma	PMID:20004781
Chronic obstructive pulmonary disease	PMID:19080468
Chronic obstructive pulmonary disease	PMID:20211002
Myasthenia gravis	PMID:10606977
cholangiocarcinoma	PMID:16292515
Myocardial infarction	PMID:15520258
Psoriasis	PMID:8763426
Psoriasis	PMID:15265530
Fatty liver disease	PMID:11718682
obesity	PMID:17027833
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)