• Gene id: 1537

Gene Summary

• Gene Symbol: CYC1   Gene   UCSC   Ensembl
• Aliases: MC3DN6, UQCR4
• Gene name: cytochrome c1
• Alternate names: cytochrome c1, heme protein, mitochondrial, complex III subunit 4, complex III subunit IV, cytochrome b-c1 complex subunit 4, cytochrome c-1, ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,
• Gene location: 8q24.3 (144095075: 144097524)     Exons: 8     NC_000008.11
• Gene summary(Entrez): This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial c
• OMIM: 604823

Protein Summary

• Protein general information: P08574  
  • Name: Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b c1 complex subunit 4) (Ubiquinol cytochrome c reductase complex cytochrome c1 subunit) (Cytochrome c 1)
  • Length: 325  
  • Mass: 35422
• Sequence:

  MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLA
  MALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAA
  EVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGV
  SLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLV
  PLVYTIKRHKWSVLKSRKLAYRPPK

• Structural information:
  • Protein Domains: (108..20-)
    (/note="Cytochrome-c)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00433"-)
  • Interpro: IPR036909  IPR002326  IPR021157  
  • PDB: 5XTE 5XTH 5XTI
  • PDBsum: 5XTE 5XTH 5XTI
  • STRING: ENSP00000317159
• Other Databases: GeneCards:  CYC1  Malacards:  CYC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042776	mitochondrial ATP synthesis coupled proton transport	IBA	biological process
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	IBA	biological process
GO:0005750	mitochondrial respiratory chain complex III	IBA	cellular component
GO:0045153	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	IBA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0009055	electron transfer activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0070469	respirasome	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0045155	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	TAS	molecular function
GO:0005739	mitochondrion	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	TAS	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0033762	response to glucagon	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005739	mitochondrion	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05010	Alzheimer disease
hsa05016	Huntington disease
hsa05012	Parkinson disease
hsa04714	Thermogenesis
hsa00190	Oxidative phosphorylation
hsa04932	Non-alcoholic fatty liver disease
hsa04260	Cardiac muscle contraction

Diseases

Associated diseases	References
Mitochondrial complex III deficiency	KEGG:H02086
Mitochondrial complex III deficiency	KEGG:H02086
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray