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Gene id 152503
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol SH3D19   Gene   UCSC   Ensembl
Aliases EBP, EVE1, Eve-1, Kryn, SH3P19
Gene name SH3 domain containing 19
Alternate names SH3 domain-containing protein 19, ADAM-binding protein Eve-1, EEN-binding protein, SH3 domain protein D19,
Gene location 4q31.3 (151325664: 151120280)     Exons: 25     NC_000004.12
Gene summary(Entrez) This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediat
OMIM 613181

Protein Summary

Protein general information Q5HYK7  

Name: SH3 domain containing protein 19 (ADAM binding protein Eve 1) (EEN binding protein) (EBP)

Length: 790  Mass: 86525

Tissue specificity: Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes. {ECO

Sequence MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGEWDSGTENR
LKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVS
SENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESV
GSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQK
KQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTEN
NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLL
EKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE
TSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELS
FKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS
Structural information
Protein Domains
(415..47-)
(/note="SH3-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
(495..55-)
(/note="SH3-2)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
(571..63-)
(/note="SH3-3)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
(-)
Interpro:  IPR035834  IPR035835  IPR036028  IPR001452  
Prosite:   PS50002
CDD:   cd11814 cd11816
MINT:  
STRING:   ENSP00000302913
Other Databases GeneCards:  SH3D19  Malacards:  SH3D19

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0007010 cytoskeleton organization
IMP biological process
GO:0022604 regulation of cell morpho
genesis
IMP biological process
GO:0005634 nucleus
IEA cellular component
GO:0005737 cytoplasm
IEA cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005515 protein binding
IPI molecular function
GO:0005886 plasma membrane
IDA cellular component
GO:0051044 positive regulation of me
mbrane protein ectodomain
proteolysis
IMP biological process
GO:0005737 cytoplasm
IEA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0005654 nucleoplasm
IDA cellular component
GO:0005829 cytosol
IDA cellular component
Associated diseases References
Male factor infertility MIK: 29961538

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
29961538 Male facto
r infertil
ity

318 (128 couple
s presenting wi
th OAT (MF) and
118 maternal a
ge-matched cont
rol (no MF) sub
jects undergoin
g infertility t
reatment, 72 su
rplus cryoprese
rved blastocyst
s)
Male infertility RNA-seq
Show abstract