• Gene id: 151525

Gene Summary

• Gene Symbol: WDSUB1   Gene   UCSC   Ensembl
• Aliases: UBOX6, WDSAM1
• Gene name: WD repeat, sterile alpha motif and U-box domain containing 1
• Alternate names: WD repeat, SAM and U-box domain-containing protein 1,
• Gene location: 2q24.2 (159286792: 159235792)     Exons: 12     NC_000002.12

Protein Summary

• Protein general information: Q8N9V3  
  • Name: WD repeat, SAM and U box domain containing protein 1
  • Length: 476  
  • Mass: 52817
• Sequence:

  MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD
  GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPN
  GSFFVTGSSCGDLTVWDDKMRCPHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHIL
  GFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGS
  MDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLVGIFKMNNIDGKELLNLTKESLADDL
  KIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAMENWISKKKRTSPMTNL
  VLPSAVLTPNRTLKMAINRWLETHQK

• Structural information:
  • Protein Domains: (332..39-)
    (/note="SAM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00184-)
    (403..47-)
    (/note="U-box"-)
  • Interpro: IPR020472  IPR011047  IPR001660  IPR013761  IPR003613   IPR015943  IPR001680  IPR019775  IPR017986  IPR013083  
  • Prosite: PS50105 PS51698 PS00678 PS50082 PS50294
  • STRING: ENSP00000387078
• Other Databases: GeneCards:  WDSUB1  Malacards:  WDSUB1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004842	ubiquitin-protein transferase activity	IEA	molecular function
GO:0016567	protein ubiquitination	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881