• Gene id: 150468

Gene Summary

• Gene Symbol: CKAP2L   Gene   UCSC   Ensembl
• Gene name: cytoskeleton associated protein 2 like
• Alternate names: cytoskeleton-associated protein 2-like, radial fiber and mitotic spindle protein, radmis,
• Gene location: 2q14.1 (112764616: 112736348)     Exons: 10     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes

Protein Summary

• Protein general information: Q8IYA6  
  • Name: Cytoskeleton associated protein 2 like (Radial fiber and mitotic spindle protein) (Radmis)
  • Length: 745  
  • Mass: 83587
• Sequence:

  MVGPGPTAAAAVEERQRKLQEYLAAKGKLKSQNTKPYLKSKNNCQNQPPSKSTIRPKNDVTNHVVLPVKPKRSIS
  IKLQPRPPNTAGSQKPKLEPPKLLGKRLTSECVSSNPYSKPSSKSFQQCEAGSSTTGELSRKPVGSLNIEQLKTT
  KQQLTDQGNGKCIDFMNNIHVENESLDNFLKETNKENLLDILTEPERKPDPKLYTRSKPKTDSYNQTKNSLVPKQ
  ALGKSSVNSAVLKDRVNKQFVGETQSRTFPVKSQQLSRGADLARPGVKPSRTVPSHFIRTLSKVQSSKKPVVKNI
  KDIKVNRSQYERPNETKIRSYPVTEQRVKHTKPRTYPSLLQGEYNNRHPNIKQDQKSSQVCIPQTSCVLQKSKAI
  SQRPNLTVGRFNSAIPSTPSIRPNGTSGNKHNNNGFQQKAQTLDSKLKKAVPQNHFLNKTAPKTQADVTTVNGTQ
  TNPNIKKKATAEDRRKQLEEWQKSKGKTYKRPPMELKTKRKVIKEMNISFWKSIEKEEEEKKAQLELSSKINNTL
  TECLNLIEGGVPSNEILNILSSIPEAEKFAKFWICKAKLLASKGTFDVIGLYEEAIKNGATPIQELRKVVLNILQ
  DSNRTTEGITSDSLVAETSITSVEELAKKMESVKSCLSPKEREQVTATPRIAKAEQHNYPGIKLQIGPIPRINGM
  PEVQDMKFITPVRRSSRIERAVSRYPEMLQEHDLVVASLDELLEVEETKCFIFRRNEALPVTLGFQTPES

• Structural information:
  • Interpro: IPR029197  
  • STRING: ENSP00000305204
• Other Databases: GeneCards:  CKAP2L  Malacards:  CKAP2L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0072686	mitotic spindle	IBA	cellular component
GO:0005829	cytosol	IBA	cellular component
GO:0005813	centrosome	IBA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0000922	spindle pole	IEA	cellular component
GO:0072686	mitotic spindle	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Filippi syndrome	KEGG:H01857
Filippi syndrome	KEGG:H01857
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881