• Gene id: 147744

Gene Summary

• Gene Symbol: TMEM190   Gene   UCSC   Ensembl
• Aliases: MDAC1
• Gene name: transmembrane protein 190
• Alternate names: transmembrane protein 190,
• Gene location: 19q13.42 (55376125: 55378245)     Exons: 5     NC_000019.10

Protein Summary

• Protein general information: Q8WZ59  
  • Name: Transmembrane protein 190
  • Length: 177  
  • Mass: 19457
• Sequence:

  MLGCGIPALGLLLLLQGSADGNGIQGFFYPWSCEGDIWDRESCGGQAAIDSPNLCLRLRCCYRNGVCYHQRPDEN
  VRRKHMWALVWTCSGLLLLSCSICLFWWAKRRDVLHMPGFLAGPCDMSKSVSLLSKHRGTKKTPSTGSVPVALSK
  ESRDVEGGTEGEGTEEGEETEGEEEED

• Structural information:
  • Protein Domains: (31..7-)
    (/note="P-type"-)
  • Interpro: IPR028248  
  • STRING: ENSP00000291934
• Other Databases: GeneCards:  TMEM190  Malacards:  TMEM190

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002079	inner acrosomal membrane	IBA	cellular component
GO:0002244	hematopoietic progenitor cell differentiation	IBA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043621	protein self-association	IEA	molecular function
GO:0002244	hematopoietic progenitor cell differentiation	IEA	biological process
GO:0002079	inner acrosomal membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R