• Gene id: 1456

Gene Summary

• Gene Symbol: CSNK1G3   Gene   UCSC   Ensembl
• Aliases: CKI-gamma 3, CSNK1G3L
• Gene name: casein kinase 1 gamma 3
• Alternate names: casein kinase I isoform gamma-3, casein kinase I,
• Gene location: 5q23.2 (123512098: 123617048)     Exons: 18     NC_000005.10
• Gene summary(Entrez): This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spl
• OMIM: 604253

Protein Summary

• Protein general information: Q9Y6M4  
  • Name: Casein kinase I isoform gamma 3 (CKI gamma 3) (EC 2.7.11.1)
  • Length: 447  
  • Mass: 51389
• Sequence:

  MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP
  MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM
  EYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKE
  QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPD
  YDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQA
  NPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETKCCCFFKRRKRKTIQRHK

• Structural information:
  • Protein Domains: (43..31-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR022247  IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • PDB: 2CHL 2IZR 2IZS 2IZT 2IZU 4G16 4G17 4HGL 4HGS 6GRO
  • PDBsum: 2CHL 2IZR 2IZS 2IZT 2IZU 4G16 4G17 4HGL 4HGS 6GRO
  • STRING: ENSP00000353904
• Other Databases: GeneCards:  CSNK1G3  Malacards:  CSNK1G3

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa04340	Hedgehog signaling pathway

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)