• Gene id: 145567

Gene Summary

• Gene Symbol: TTC7B   Gene   UCSC   Ensembl
• Aliases: TTC7L1, c14_5685
• Gene name: tetratricopeptide repeat domain 7B
• Alternate names: tetratricopeptide repeat protein 7B, TPR repeat protein 7-like-1, TPR repeat protein 7B, tetratricopeptide repeat domain 7 like 1, tetratricopeptide repeat protein 7-like-1,
• Gene location: 14q32.11 (90816478: 90524563)     Exons: 22     NC_000014.9

Protein Summary

• Protein general information: Q86TV6  
  • Name: Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7 like 1) (TPR repeat protein 7 like 1)
  • Length: 843  
  • Mass: 94179
• Sequence:

  MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRGPKPQL
  TEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRVIAEAYATKGL
  CLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRA
  HVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN
  TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGR
  RGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWLEE
  AEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQL
  AISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD
  EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEV
  ASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEAR
  RWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTAL
  ELEASSPAVPFTIIPRVL

• Structural information:
  • Interpro: IPR013026  IPR011990  IPR019734  
  • Prosite: PS50005 PS50293
  • PDB: 5DSE 6BQ1
  • PDBsum: 5DSE 6BQ1
  • STRING: ENSP00000336127
• Other Databases: GeneCards:  TTC7B  Malacards:  TTC7B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0072659	protein localization to plasma membrane	IBA	biological process
GO:0046854	phosphatidylinositol phosphorylation	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0072659	protein localization to plasma membrane	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0072659	protein localization to plasma membrane	IDA	biological process
GO:0046854	phosphatidylinositol phosphorylation	IDA	biological process
GO:0046854	phosphatidylinositol phosphorylation	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq