• Gene id: 145553

Gene Summary

• Gene Symbol: MDP1   Gene   UCSC   Ensembl
• Aliases: FN6PASE, MDP-1
• Gene name: magnesium dependent phosphatase 1
• Alternate names: magnesium-dependent phosphatase 1, fructosamine-6-phosphatase,
• Gene location: 14q12 (24216069: 24213936)     Exons: 6     NC_000014.9

Protein Summary

• Protein general information: Q86V88  
  • Name: Magnesium dependent phosphatase 1 (MDP 1) (EC 3.1.3. ) (EC 3.1.3.48)
  • Length: 176  
  • Mass: 20109
• Sequence:

  MARLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQDVRLYPEVPEVLKRLQSLGVPGAAASRTSEIE
  GANQLLELFDLFRYFVHREIYPGSKITHFERLQQKTGIPFSQMIFFDDERRNIVDVSKLGVTCIHIQNGMNLQTL
  SQGLETFAKAQTGPLRSSLEESPFEA

• Structural information:
  • Interpro: IPR036412  IPR023214  IPR010033  IPR035679  IPR010036  
  • CDD: cd07501
  • PDB: 2WM8
  • PDBsum: 2WM8
  • STRING: ENSP00000288087
• Other Databases: GeneCards:  MDP1  Malacards:  MDP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003993	acid phosphatase activity	IBA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0030389	fructosamine metabolic process	IEA	biological process
GO:0016791	phosphatase activity	IEA	molecular function
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0006470	protein dephosphorylation	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray