• Gene id: 140880

Gene Summary

• Gene Symbol: CST11   Gene   UCSC   Ensembl
• Aliases: CST8L, CTES2, SC13, dJ322G13.6
• Gene name: cystatin 11
• Alternate names: cystatin-11, SC13delta, cystatin-related epididymal-specific protein, epididymis secretory sperm binding protein,
• Gene location: 20p11.21 (23452875: 23450411)     Exons: 3     NC_000020.11
• Gene summary(Entrez): The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory
• OMIM: 609731

Protein Summary

• Protein general information: Q9H112  
  • Name: Cystatin 11
  • Length: 138  
  • Mass: 16506
  • Tissue specificity: Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level). {ECO
• Sequence:

  MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQR
  QVTDHLEYHLNVEMQWTTCQKPETTNCVPQERELHKQVNCFFSVFAVPWFEQYKILNKSCSSD

• Structural information:
  • Interpro: IPR042930  IPR000010  
  • CDD: cd00042
  • STRING: ENSP00000366208
• Other Databases: GeneCards:  CST11  Malacards:  CST11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061827	sperm head	IBA	cellular component
GO:0050829	defense response to Gram-negative bacterium	IBA	biological process
GO:0036126	sperm flagellum	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	molecular function
GO:0050829	defense response to Gram-negative bacterium	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0030414	peptidase inhibitor activity	IEA	molecular function
GO:0010466	negative regulation of peptidase activity	IEA	biological process
GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	molecular function
GO:0042742	defense response to bacterium	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0010951	negative regulation of endopeptidase activity	IEA	biological process
GO:0010951	negative regulation of endopeptidase activity	IEA	biological process
GO:0031640	killing of cells of other organism	IDA	biological process
GO:0036126	sperm flagellum	IDA	cellular component
GO:0061827	sperm head	IDA	cellular component
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0005634	nucleus	IMP	cellular component
GO:0030521	androgen receptor signaling pathway	ISS	biological process
GO:0005737	cytoplasm	IMP	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq