• Gene id: 140838

Gene Summary

• Gene Symbol: NANP   Gene   UCSC   Ensembl
• Aliases: C20orf147, HDHD4, dJ694B14.3
• Gene name: N-acetylneuraminic acid phosphatase
• Alternate names: N-acylneuraminate-9-phosphatase, Neu5Ac-9-Pase, haloacid dehalogenase-like hydrolase domain containing 4, haloacid dehalogenase-like hydrolase domain-containing protein 4,
• Gene location: 20p11.21 (25624013: 25612934)     Exons: 2     NC_000020.11
• OMIM: 610763

Protein Summary

• Protein general information: Q8TBE9  
  • Name: N acylneuraminate 9 phosphatase (EC 3.1.3.29) (Haloacid dehalogenase like hydrolase domain containing protein 4) (Neu5Ac 9 Pase)
  • Length: 248  
  • Mass: 27813
• Sequence:

  MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNTCITDLRTSH
  WEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSY
  FDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHY
  MVSSVLELPALLQSIDCKVSMST

• Structural information:
  • Interpro: IPR036412  IPR006439  IPR011950  IPR041492  IPR023214  
  • PDB: 2W4M 4KNV 4KNW
  • PDBsum: 2W4M 4KNV 4KNW
  • STRING: ENSP00000302441
• Other Databases: GeneCards:  NANP  Malacards:  NANP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0050124	N-acylneuraminate-9-phosphatase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0050124	N-acylneuraminate-9-phosphatase activity	IEA	molecular function
GO:0046380	N-acetylneuraminate biosynthetic process	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0006045	N-acetylglucosamine biosynthetic process	IEA	biological process
GO:0046380	N-acetylneuraminate biosynthetic process	IDA	biological process
GO:0050124	N-acylneuraminate-9-phosphatase activity	IDA	molecular function
GO:0005575	cellular_component	ND	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00520	Amino sugar and nucleotide sugar metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)