Gene id |
140832 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
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Gene Symbol |
WFDC10A Gene UCSC Ensembl |
Aliases |
C20orf146, WAP10, dJ688G8.3 |
Gene name |
WAP four-disulfide core domain 10A |
Alternate names |
WAP four-disulfide core domain protein 10A, putative protease inhibitor WAP10A, |
Gene location |
20q13.12 (45629738: 45631195) Exons: 2 NC_000020.11
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Gene summary(Entrez) |
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFD
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Protein Summary
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Protein general information
| Q9H1F0
Name: WAP four disulfide core domain protein 10A (Putative protease inhibitor WAP10A)
Length: 79 Mass: 8943
|
Sequence |
MAPQTLLPVLVLCVLLLQAQGGYRDKKRMQKTQLSPEIKVCQQQPKLYLCKHLCESHRDCQANNICCSTYCGNVC MSIL
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Structural information |
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Other Databases |
GeneCards: WFDC10A  Malacards: WFDC10A |
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GO accession | Term name | Evidence code | Go category |
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GO:0045087 |
innate immune response
|
IBA |
biological process |
GO:0019731 |
antibacterial humoral res ponse
|
IBA |
biological process |
GO:0005615 |
extracellular space
|
IBA |
cellular component |
GO:0004867 |
serine-type endopeptidase inhibitor activity
|
IBA |
molecular function |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0030414 |
peptidase inhibitor activ ity
|
IEA |
molecular function |
GO:0030414 |
peptidase inhibitor activ ity
|
IEA |
molecular function |
GO:0010466 |
negative regulation of pe ptidase activity
|
IEA |
biological process |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0004867 |
serine-type endopeptidase inhibitor activity
|
IEA |
molecular function |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0010951 |
negative regulation of en dopeptidase activity
|
IEA |
biological process |
GO:0010951 |
negative regulation of en dopeptidase activity
|
IEA |
biological process |
|
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Associated diseases |
References |
Teratozoospermia | MIK: 17327269 |
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PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
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13 (5 controls, 8 cases)
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Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
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Show abstract |
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