• Gene id: 140801

Gene Summary

• Gene Symbol: RPL10L   Gene   UCSC   Ensembl
• Aliases: RPL10_5_1358
• Gene name: ribosomal protein L10 like
• Alternate names: 60S ribosomal protein L10-like, large ribosomal subunit protein uL16-like,
• Gene location: 14q21.2 (46651780: 46651009)     Exons: 1     NC_000014.9
• Gene summary(Entrez): This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene

Protein Summary

• Protein general information: Q96L21  
  • Name: 60S ribosomal protein L10 like (Large ribosomal subunit protein uL16 like)
  • Length: 214  
  • Mass: 24519
  • Tissue specificity: Testis specific. {ECO
• Sequence:

  MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQLSSEALEAARICANKY
  MVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIE
  ALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS

• Structural information:
  • Interpro: IPR001197  IPR016180  IPR036920  IPR018255  
  • Prosite: PS01257
  • CDD: cd01433
  • PDB: 4UG0 4V6X 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP
  • PDBsum: 4UG0 4V6X 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6QZP
  • STRING: ENSP00000298283
• Other Databases: GeneCards:  RPL10L  Malacards:  RPL10L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000027	ribosomal large subunit assembly	IBA	biological process
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IEA	cellular component
GO:0005844	polysome	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	NAS	cellular component
GO:0007283	spermatogenesis	IEP	biological process
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Oligozoospermia	MIK: 32111475
Male factor infertility	MIK: 32111475
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
32111475	Oligozoospermia, Male factor infertility	c.A257C: p.H86P		637 (414 patients with oligo-/azoospermia and 223 fertile subjects)	Male infertility	NGS
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray