• Gene id: 140739

Gene Summary

• Gene Symbol: UBE2F   Gene   UCSC   Ensembl
• Aliases: NCE2
• Gene name: ubiquitin conjugating enzyme E2 F (putative)
• Alternate names: NEDD8-conjugating enzyme UBE2F, NEDD8 carrier protein UBE2F, NEDD8 protein ligase UBE2F, NEDD8-conjugating enzyme 2, RING-type E3 NEDD8 transferase UBE2F, ubiquitin-conjugating enzyme E2F (putative),
• Gene location: 2q37.3 (237966944: 238042781)     Exons: 12     NC_000002.12
• OMIM: 617700

Protein Summary

• Protein general information: Q969M7  
  • Name: NEDD8 conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8 conjugating enzyme 2) (RING type E3 NEDD8 transferase UBE2F) (Ubiquitin conjugating enzyme E2 F)
  • Length: 185  
  • Mass: 21077
  • Tissue specificity: Widely expressed (at protein level). {ECO
• Sequence:

  MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGY
  YQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDL
  LNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR

• Structural information:
  • Interpro: IPR000608  IPR023313  IPR016135  
  • Prosite: PS00183 PS50127
  • CDD: cd00195
  • PDB: 2EDI 3FN1 4GBA
  • PDBsum: 2EDI 3FN1 4GBA
  • STRING: ENSP00000478474
• Other Databases: GeneCards:  UBE2F  Malacards:  UBE2F

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019788	NEDD8 transferase activity	IBA	molecular function
GO:0045116	protein neddylation	IBA	biological process
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0045116	protein neddylation	IDA	biological process
GO:0061654	NEDD8 conjugating enzyme activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019788	NEDD8 transferase activity	TAS	molecular function
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045116	protein neddylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)