• Gene id: 139081

Gene Summary

• Gene Symbol: MAGEC3   Gene   UCSC   Ensembl
• Aliases: CT7.2, HCA2, MAGE-C3, MAGEC4
• Gene name: MAGE family member C3
• Alternate names: melanoma-associated antigen C3, MAGE family testis and tumor-specific protein, MAGE-C3 antigen, cancer/testis antigen 7.2, cancer/testis antigen family 7, member 2, hepatocellular carcinoma-associated antigen 2, hepatocellular carcinoma-associated protein HCA2, ,
• Gene location: Xq27.2 (141838315: 141898141)     Exons: 13     NC_000023.11
• Gene summary(Entrez): This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcr
• OMIM: 300469

Protein Summary

• Protein general information: Q8TD91  
  • Name: Melanoma associated antigen C3 (Cancer/testis antigen 7.2) (CT7.2) (Hepatocellular carcinoma associated antigen 2) (MAGE C3 antigen)
  • Length: 643  
  • Mass: 71909
  • Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins. {ECO
• Sequence:

  MLLPCHWVLDATFSDGSLGQWVKNTCATYALSPVVLPPQPQPRKKATDKDYSAFHLGHLREVRLFLRGGTSDQRM
  DSLVLCPTYFKLWRTLSGSPGLQLSDLHFGSQPEGKFSLRRAVSVKQREEPQDWPLNEKRTLWKDSDLPTWRRGT
  GYTLSLPAVSPGKRLWGEKAGSLPESEPLFTYTLDEKVDKLVQFLLLKYQAKEPLTRAEMQMNVINTYTGYFPMI
  FRKAREFIEILFGISLTEVDPDHFYVFVNTLDLTCEGSLSDEQGMPQNRLLILILSVIFIKGNCASEEVIWEVLN
  AIGPWSALAGFADVLSRLALWESEGPEAFCEESGLRSAEGSVLDLANPQGLAGHRQEDGRRGLTEASPQQKKGGE
  DEDMPAAGMPPLPQSPPEIPPQGPPKISPQGPPQSPPQSPLDSCSSPLLWTRLDEESSSEEEDTATWHALPESES
  LPRYALDEKVAELVQFLLLKYQTKEPVTKAEMLTTVIKKYKDYFPMIFGKAHEFIELIFGIALTDMDPDNHSYFF
  EDTLDLTYEGSLIDDQGMPKNCLLILILSMIFIKGSCVPEEVIWEVLSAIGPIQRPAREVLEFLSKLSSIIPSAF
  PSWYMDALKDMEDRAQAIIDTTDDATAMASASPSVMSTNFCPE

• Structural information:
  • Protein Domains: (184..38-)
    (/note="MAGE-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00127-)
    (456..64-)
    (/note="MAGE-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00127"-)
  • Interpro: IPR037445  IPR041898  IPR041899  IPR002190  
  • Prosite: PS50838
  • STRING: ENSP00000298296
• Other Databases: GeneCards:  MAGEC3  Malacards:  MAGEC3

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)