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Gene id 1390
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CREM   Gene   UCSC   Ensembl
Aliases CREM-2, ICER, hCREM-2
Gene name cAMP responsive element modulator
Alternate names cAMP-responsive element modulator, CREM 2alpha-b protein, CREM 2beta-a protein, cAMP response element modulator, inducible cAMP early repressor ICER,
Gene location 10p11.21 (35126829: 35212957)     Exons: 18     NC_000010.11
Gene summary(Entrez) This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other comple
OMIM 123812

SNPs
rs4934540

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.35185771T>A
NC_000010.11   g.35185771T>C
NC_000010.10   g.35474699T>A
NC_000010.10   g.35474699T>C
NG_029065.1   g.63899T>A
NG_029065.1   g.63899T>C|SEQ=[T/A/C]|GENE=CREM

rs2295415

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000010.11   g.35212510A>G
NC_000010.10   g.35501438A>G
NG_029065.1   g.90638A>G
NM_183013.3   c.*1112A>G
NM_183013.2   c.*1112A>G
NM_181571.3   c.*707A>G
NM_181571.2   c.*707A>G
NM_182769.3   c.*707A>G
NM_182769.2   c.*707A>G
NM_182770.3   c.*707A>G
NM_182770.2   c.*70

Protein Summary
Protein general information Q03060  

Name: cAMP responsive element modulator (Inducible cAMP early repressor) (ICER)

Length: 361  Mass: 38,940

Sequence MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQ
LPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPG
VPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIV
QYAAQSADGTQQFFVPGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEE
ATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
Structural information
Protein Domains
 KID. (104-163)
bZIP. (302-361)
Interpro:  IPR004827  IPR003102  IPR001630  
Prosite:   PS50217 PS00036 PS50953
MINT:  
Other Databases GeneCards:  CREM  Malacards:  CREM

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0001046 core promoter sequence-sp
ecific DNA binding
 IEA molecular function
GO:0003677 DNA binding
 NAS molecular function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
 IEA molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005634 nucleus
 NAS cellular component
GO:0005667 transcription factor comp
lex
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0006006 glucose metabolic process
 IEA biological process
GO:0006351 transcription, DNA-templa
ted
 IEA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 NAS biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IDA biological process
GO:0006631 fatty acid metabolic proc
ess
 IEA biological process
GO:0006687 glycosphingolipid metabol
ic process
 IEA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0007275 multicellular organism de
velopment
 IEA biological process
GO:0007283 spermatogenesis
 IEA biological process
GO:0008140 cAMP response element bin
ding protein binding
 NAS molecular function
GO:0030154 cell differentiation
 IEA biological process
GO:0032922 circadian regulation of g
ene expression
 IEA biological process
GO:0042752 regulation of circadian r
hythm
 IEA biological process
GO:0045892 negative regulation of tr
anscription, DNA-template
d
 IEA biological process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
 IEA biological process
GO:0048384 retinoic acid receptor si
gnaling pathway
 IEA biological process
GO:0051591 response to cAMP
 IEA biological process
GO:0001046 core promoter sequence-sp
ecific DNA binding
 IEA molecular function
GO:0003677 DNA binding
 IEA molecular function
GO:0003677 DNA binding
 IEA molecular function
GO:0003677 DNA binding
 IEA molecular function
GO:0003677 DNA binding
 NAS molecular function
GO:0003700 transcription factor acti
vity, sequence-specific D
NA binding
 IEA molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 TAS cellular component
GO:0005634 nucleus
 NAS cellular component
GO:0005667 transcription factor comp
lex
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0006006 glucose metabolic process
 IEA biological process
GO:0006351 transcription, DNA-templa
ted
 IEA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IEA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IEA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 NAS biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IDA biological process
GO:0006631 fatty acid metabolic proc
ess
 IEA biological process
GO:0006687 glycosphingolipid metabol
ic process
 IEA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0007275 multicellular organism de
velopment
 IEA biological process
GO:0007283 spermatogenesis
 IEA biological process
GO:0007283 spermatogenesis
 IEA biological process
GO:0007623 circadian rhythm
 IEA biological process
GO:0008140 cAMP response element bin
ding protein binding
 NAS molecular function
GO:0030154 cell differentiation
 IEA biological process
GO:0032922 circadian regulation of g
ene expression
 IEA biological process
GO:0042752 regulation of circadian r
hythm
 IEA biological process
GO:0043565 sequence-specific DNA bin
ding
 IEA molecular function
GO:0045892 negative regulation of tr
anscription, DNA-template
d
 IEA biological process
GO:0045944 positive regulation of tr
anscription from RNA poly
merase II promoter
 IEA biological process
GO:0048384 retinoic acid receptor si
gnaling pathway
 IEA biological process
GO:0048511 rhythmic process
 IEA biological process
GO:0051591 response to cAMP
 IEA biological process
GO:0003677 DNA binding
 NAS molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005634 nucleus
 TAS cellular component
GO:0005634 nucleus
 NAS cellular component
GO:0006355 regulation of transcripti
on, DNA-templated
 NAS biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IDA biological process
GO:0007165 signal transduction
 TAS biological process
GO:0008140 cAMP response element bin
ding protein binding
 NAS molecular function

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa04261Adrenergic signaling in cardiomyocytes

Diseases

Expand All | Collapse All
Associated diseases References
Alzheimer's disease GAD: 16385451
Panic disorder GAD: 12555239
Azoospermia MIK: 20378615
Male factor infertility MIK: 24943041
Non obstructive azoospermia MIK: 24943041
Oligozoospermia MIK: 9531892
Spermatogenesis defects MIK: 11044457
Spermatogenesis defects MIK: 10591614
Round spermatid maturation arrest MIK: 9510006
Oligozoospermia MIK: 21507395
Ambiguous genitalia INFBASE: 9531892
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Associated with gene transcription dring spermatogenesis MIK: 20488182
Associated with male sterility and stage -specific arrest of sperm maturation as the spermatids undergo apoptosis MIK: 14654248
Associated with spermatogenesis MIK: 8114765
Azoospermia MIK: 9531892
Oligozoospermia MIK: 9531892
Hypospermatogenesis MIK: 28361989
Idiopathic nonobstructive azoospermia MIK: 24943041
Male infertility MIK: 14511788
Oligozoospermia MIK: 21989496
Role in spermatogenesis MIK: 14742698
Round spermatid maturation arrest MIK: 9510006
Spermatogenic defects MIK: 31037746
Teratozoospermia MIK: 17327269
Unexplained infertility MIK: 25753583

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24943041 Idiopathic
nonobstru
ctive azoo
spermia
 CREM (rs4934540, rs2295415) Chinese
 729 (361 idiopa
thic nonobstruc
tive azoospermi
a NOA patients
and 368 control
s)
 Male infertility CREM
ACT
KIF17b
and SPAG8
 Show abstract
21507395 Oligozoosp
ermia
132 (24 abnorma
lly low protami
ne 1/protamine
2 (P1/P2) ratio
, 36 high prota
mine 1/protamin
e 2 (P1/P2) rat
io, 32 patients
with oligozoos
permia, 40 norm
ozoospermic, fe
rtile controls
with normal P1/
P2 ratio)
 Male infertility CREM
 Show abstract
16143638 Male infer
tility
 CREM (IVS2 (IVS2-58_55insT) ) Sloveni
an
 19 (13 Slovenia
n men with roun
d spermatid arr
est, in six con
trols)
 Male infertility CREM
 Show abstract
14511788 Male infer
tility

Male infertility CREM
 Show abstract
11044457 Impaired s
permatogen
esis
6 (4 testis wit
h normal sperma
togenesis, 2 wi
th impaired spe
rmatogenesis)
 Male infertility CREM
 Show abstract
10591614 Impaired s
permatogen
esis, roun
d-spermati
d maturati
on arrest
36 (20 men with
normal spermat
ogenesis, 16 me
n with round sp
ermatid maturat
ion arrest)
 Male infertility CREM
TP1
 Show abstract
9531892 Azoospermi
a, Oligozo
ospermia
38 azoospermic,
severely oligo
zoospermic male
s
 Male infertility 5 alpha-reductase type 2
 Show abstract
9510006 Round sper
matid matu
ration arr
est
26 infertile pa
tients (10 with
round spermati
d maturation ar
rest, 10 mixed
atrophy, 6 pros
tate cancer pat
ients)
 Male infertility CREM
 Show abstract
20488182 Associated
with gene
transcrip
tion dring
spermatog
enesis

Male infertility
Show abstract
14742698 Role in sp
ermatogene
sis

Male infertility
Show abstract
14654248 Associated
with male
sterility
and stage
-specific
arrest of
sperm mat
uration as
the sperm
atids unde
rgo apopto
sis

Male infertility
Show abstract
9768690 Oligoazoos
permia, Ma
y be relat
ed to impa
ired sperm
atogenesis

Male infertility
Show abstract
8114765 Associated
with sper
matogenesi
s

Male infertility CREM
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28361989 Hyposperma
togenesis
6 (3 controls,
3 Klienfelter s
yndrome
 Male infertility Microarray
 Show abstract
31037746 Spermatoge
nic defect
s
16 (1 control,
15 cases)
 Male infertility GSE6023 analyzed using GEO2R
 Show abstract
25753583 Unexplaine
d infertil
ity
46 (17 fertile
men, 29 male pa
tients)
 Male infertility Microarray
 Show abstract
21989496 Oligozoosp
ermia
11 (8 infertile
and 3 fertile
men)
 Male infertility Microarray
 Show abstract