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Gene id 1385
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CREB1   Gene   UCSC   Ensembl
Aliases CREB, CREB-1
Gene name cAMP responsive element binding protein 1
Alternate names cyclic AMP-responsive element-binding protein 1, active transcription factor CREB, cAMP-response element-binding protein-1, cyclic adenosine 3',5'-monophosphate response element binding protein, cyclic adenosine 3',5'-monophosphate response element-binding pr,
Gene location 2q33.3 (207529891: 207605988)     Exons: 13     NC_000012.12
Gene summary(Entrez) This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kin
OMIM 123810

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04668TNF signaling pathway
hsa04024cAMP signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04612Antigen processing and presentation
hsa04911Insulin secretion
hsa04922Glucagon signaling pathway
hsa04915Estrogen signaling pathway
hsa04926Relaxin signaling pathway
hsa04918Thyroid hormone synthesis
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04916Melanogenesis
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04927Cortisol synthesis and secretion
hsa04261Adrenergic signaling in cardiomyocytes
hsa04962Vasopressin-regulated water reabsorption
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04380Osteoclast differentiation
hsa04211Longevity regulating pathway
hsa04710Circadian rhythm
hsa04713Circadian entrainment
hsa04714Thermogenesis
hsa05203Viral carcinogenesis
hsa05215Prostate cancer
hsa05016Huntington disease
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa04931Insulin resistance
hsa04934Cushing syndrome
hsa05152Tuberculosis
hsa05166Human T-cell leukemia virus 1 infection
hsa05161Hepatitis B
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05165Human papillomavirus infection
hsa04151PI3K-Akt signaling pathway
hsa04915Estrogen signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04728Dopaminergic synapse
hsa04714Thermogenesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04022cGMP-PKG signaling pathway
hsa05203Viral carcinogenesis
hsa04024cAMP signaling pathway
hsa05163Human cytomegalovirus infection
hsa04911Insulin secretion
hsa04725Cholinergic synapse
hsa04152AMPK signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04713Circadian entrainment
hsa05165Human papillomavirus infection
hsa04935Growth hormone synthesis, secretion and action
hsa04211Longevity regulating pathway
hsa05031Amphetamine addiction
hsa04931Insulin resistance
hsa04918Thyroid hormone synthesis
hsa05034Alcoholism
hsa05016Huntington disease
hsa04916Melanogenesis
hsa04926Relaxin signaling pathway
hsa04922Glucagon signaling pathway
hsa05161Hepatitis B
hsa04962Vasopressin-regulated water reabsorption
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa04934Cushing syndrome
hsa05215Prostate cancer
hsa04927Cortisol synthesis and secretion
hsa05030Cocaine addiction
hsa04668TNF signaling pathway
hsa04924Renin secretion
hsa05152Tuberculosis
hsa04612Antigen processing and presentation
hsa04710Circadian rhythm
hsa04380Osteoclast differentiation

Diseases

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Associated diseases References
Inflammation GAD: 17827388
Asthma GAD: 12724032
Diabetes GAD: 20682687
Alzheimer's disease GAD: 19141999
Bulimia GAD: 20468064
Depression GAD: 19844206
Major depressive disorder GAD: 19194961
Mood disorders GAD: 15999345
Azoospermia MIK: 21625623
Associated with spermatogenesis MIK: 8702738
Critical for germ cell survival MIK: 11159868
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Associated with spermatogenesis MIK: 8702738
Critical for germ cell survival MIK: 11159868
Impaired spermatogenesis MIK: 11159868
Cryptorchidism MIK: 28606200
Impaired spermatogenesis MIK: 21625623
Azoospermia MIK: 21625623
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
11159868 Critical f
or germ ce
ll surviva
l, Impaire
d spermato
genesis

Male infertility
Show abstract
8702738 Associated
with sper
matogenesi
s

Male infertility
Show abstract
21625623 Impaired s
permatogen
esis, Azoo
spermia

Male infertility
Show abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract