• Gene id: 1382

Gene Summary

• Gene Symbol: CRABP2   Gene   UCSC   Ensembl
• Aliases: CRABP-II, RBP6
• Gene name: cellular retinoic acid binding protein 2
• Alternate names: cellular retinoic acid-binding protein 2, cellular retinoic acid-binding protein II,
• Gene location: 1q23.1 (156705815: 156699605)     Exons: 5     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate
• OMIM: 400030

Protein Summary

• Protein general information: P29373  
  • Name: Cellular retinoic acid binding protein 2 (Cellular retinoic acid binding protein II) (CRABP II)
  • Length: 138  
  • Mass: 15693
• Sequence:

  MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQ
  TVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

• Structural information:
  • Interpro: IPR012674  IPR031281  IPR000463  IPR031259  IPR000566  
  • Prosite: PS00214
  • PDB: 1BLR 1BM5 1CBQ 1CBS 1XCA 2CBS 2FR3 2FRS 2FS6 2FS7 2G78 2G79 2G7B 3CBS 3CR6 3CWK 3D95 3D96 3D97 3F8A 3F9D 3FA6 3FA7 3FA8 3FA9 3FEK 3FEL 3FEN 3FEP 3I17 4I9R 4I9S 4M6S 4M7M 4QGV 4QGW 4QGX 4YBP 4YBU 4YCE 4YCH 4YDA 4YDB 4YFP 4YFQ 4YFR 4YGG 4YGH 4YGZ 4YH0 4YKM 4YKO 5HZQ 5OGB 6HKR 6MOP 6MOQ 6MOR 6MOV 6MOW 6MOX 6MPK 6MQI 6MQ
  • PDBsum: 1BLR 1BM5 1CBQ 1CBS 1XCA 2CBS 2FR3 2FRS 2FS6 2FS7 2G78 2G79 2G7B 3CBS 3CR6 3CWK 3D95 3D96 3D97 3F8A 3F9D 3FA6 3FA7 3FA8 3FA9 3FEK 3FEL 3FEN 3FEP 3I17 4I9R 4I9S 4M6S 4M7M 4QGV 4QGW 4QGX 4YBP 4YBU 4YCE 4YCH 4YDA 4YDB 4YFP 4YFQ 4YFR 4YGG 4YGH 4YGZ 4YH0 4YKM 4YKO 5HZQ 5OGB 6HKR 6MOP 6MOQ 6MOR 6MOV 6MOW 6MOX 6MPK 6MQI 6MQ
  • STRING: ENSP00000482841
• Other Databases: GeneCards:  CRABP2  Malacards:  CRABP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008289	lipid binding	IEA	molecular function
GO:0001972	retinoic acid binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0048385	regulation of retinoic acid receptor signaling pathway	IEA	biological process
GO:0016918	retinal binding	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0019841	retinol binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005501	retinoid binding	TAS	molecular function
GO:0006355	regulation of transcription, DNA-templated	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0008544	epidermis development	TAS	biological process
GO:0030332	cyclin binding	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048672	positive regulation of collateral sprouting	IEA	biological process
GO:0042573	retinoic acid metabolic process	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0035115	embryonic forelimb morphogenesis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0001972	retinoic acid binding	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray