• Gene id: 137970

Gene Summary

• Gene Symbol: UNC5D   Gene   UCSC   Ensembl
• Aliases: PRO34692, Unc5h4
• Gene name: unc-5 netrin receptor D
• Alternate names: netrin receptor UNC5D, netrin receptor Unc5h4, protein unc-5 homolog 4, protein unc-5 homolog D, unc-5 homolog 4, unc-5 homolog D,
• Gene location: 8p12 (35235474: 35796549)     Exons: 21     NC_000008.11
• OMIM: 616466

Protein Summary

• Protein general information: Q6UXZ4  
  • Name: Netrin receptor UNC5D (Protein unc 5 homolog 4) (Protein unc 5 homolog D)
  • Length: 953  
  • Mass: 105880
• Sequence:

  MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPESIPSAPGTLPHFIEEPDDAYIIKSNPIALRC
  KARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKA
  SVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSD
  SGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKIT
  CTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIE
  NASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTV
  SRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRN
  KMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLS
  PEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGT
  YALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSL
  QISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSIL
  ESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAV
  ILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL

• Structural information:
  • Protein Domains: (54..15-)
    (/note="Ig-like-)
    (153..24-)
    (/note="Ig-like-C2-type)
    (252..30-)
    1 (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00210-)
    (308..36-)
    2 (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU0021-)
  • Interpro: IPR011029  IPR000488  IPR007110  IPR036179  IPR013783   IPR013098  IPR003599  IPR003598  IPR000884  IPR036383  IPR037936  IPR042058  IPR033772  IPR000906  
  • Prosite: PS50835 PS50092 PS51145
  • CDD: cd08801
  • STRING: ENSP00000385143
• Other Databases: GeneCards:  UNC5D  Malacards:  UNC5D

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007411	axon guidance	IBA	biological process
GO:0005042	netrin receptor activity	IBA	molecular function
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IDA	biological process
GO:0005042	netrin receptor activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0038007	netrin-activated signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:2001222	regulation of neuron migration	IEA	biological process
GO:0021859	pyramidal neuron differentiation	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0007411	axon guidance	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R