• Gene id: 136853

Gene Summary

• Gene Symbol: SSC4D   Gene   UCSC   Ensembl
• Aliases: S4D-SRCRB, SRCRB-S4D, SRCRB4D
• Gene name: scavenger receptor cysteine rich family member with 4 domains
• Alternate names: scavenger receptor cysteine-rich domain-containing group B protein, SRCRB4D, four scavenger receptor cysteine-rich domains-containing protein, scavenger receptor cysteine rich domain containing, group B (4 domains), scavenger receptor cysteine rich family, 4 ,
• Gene location: 7q11.23 (76410024: 76389336)     Exons: 12     NC_000007.14
• Gene summary(Entrez): The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive im
• OMIM: 607639

Protein Summary

• Protein general information: Q8WTU2  
  • Name: Scavenger receptor cysteine rich domain containing group B protein (Four scavenger receptor cysteine rich domains containing protein) (S4D SRCRB)
  • Length: 575  
  • Mass: 60819
• Sequence:

  MHKEAEMLIGPQLDEKRWGWRLGDGSAAPPFLPQALSFLLLLPLASALQPTPLPFQELRLVGGPSRCRGRLEVMH
  GGSWGSVCDDDWDVVDANVVCRQLGCGLALPVPRPLAFGQGRGPILLDNVECRGQEAALSECGSRGWGVHNCFHY
  EDVAVLCDEFLPTQPPTRKMLTSRAPPTTLPNGKSEGSVRLVGGANLCQGRVEILHSGLWGTVCDDDWGLPDAAV
  VCRQLGCGAAMAATTNAFFGYGTGHILLDNVHCEGGEPRLAACQSLGWGVHNCGHHEDAGALCAGLGPPTLTALP
  SSATREDWAWQTDPSATGVGPQPSRETALLTTAAWAAGKKSGRLRLVGGPGPCRGRVEVLHAGGWGTVCDDDWDF
  ADARVACREAGCGPALGATGLGHFGYGRGPVLLDNVGCAGTEARLSDCFHLGWGQHNCGHHEDAGALCAGPEELG
  LQVQQDGSETTRVPTPRPRDGHLRLVNGAHRCEGRVELYLGQRWGTVCDDAWDLRAAGVLCRQLGCGQALAAPGE
  AHFGPGRGPILLDNVKCRGEESALLLCSHIRWDAHNCDHSEDASVLCQPS

• Structural information:
  • Protein Domains: (58..15-)
    (/note="SRCR-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00196-)
    (189..28-)
    (/note="SRCR-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00196-)
    (344..44-)
    (/note="SRCR-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00196-)
    (-)
  • Interpro: IPR001190  IPR017448  IPR036772  
  • Prosite: PS00420 PS50287
  • STRING: ENSP00000275560
• Other Databases: GeneCards:  SSC4D  Malacards:  SSC4D

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0005044	scavenger receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881