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Gene id 1366
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CLDN7   Gene   UCSC   Ensembl
Aliases CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1
Gene name claudin 7
Alternate names claudin-7, clostridium perfringens enterotoxin receptor-like 2, epididymis secretory sperm binding protein,
Gene location 17p13.1 (7263192: 7259902)     Exons: 5     NC_000017.11
Gene summary(Entrez) This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula
OMIM 606106

Protein Summary
Protein general information O95471  

Name: Claudin 7 (CLDN 7)

Length: 211  Mass: 22418

Tissue specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular

Sequence MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSA
ALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVACSWYGHQIVTDFYN
PLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEYV
Structural information
Interpro:  IPR006187  IPR003552  IPR017974  IPR004031  
Prosite:   PS01346
MINT:  
STRING:   ENSP00000353475
Other Databases GeneCards:  CLDN7  Malacards:  CLDN7

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0005923 bicellular tight junction
 IBA cellular component
GO:0070830 bicellular tight junction
assembly
 IBA biological process
GO:0007155 cell adhesion
 IBA biological process
GO:0005886 plasma membrane
 IBA cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005198 structural molecule activ
ity
 IEA molecular function
GO:0005923 bicellular tight junction
 IEA cellular component
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0030054 cell junction
 IEA cellular component
GO:0005923 bicellular tight junction
 IEA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:0016020 membrane
 IEA cellular component
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0050839 cell adhesion molecule bi
nding
 IEA molecular function
GO:0019904 protein domain specific b
inding
 IEA molecular function
GO:0007162 negative regulation of ce
ll adhesion
 IEA biological process
GO:0016327 apicolateral plasma membr
ane
 IEA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:2000147 positive regulation of ce
ll motility
 IEA biological process
GO:0045471 response to ethanol
 IEA biological process
GO:0043066 negative regulation of ap
optotic process
 IEA biological process
GO:0031333 negative regulation of pr
otein-containing complex
assembly
 IEA biological process
GO:0016328 lateral plasma membrane
 IEA cellular component
GO:0016323 basolateral plasma membra
ne
 IEA cellular component
GO:0008284 positive regulation of ce
ll population proliferati
on
 IEA biological process
GO:0016328 lateral plasma membrane
 IEA cellular component
GO:0016323 basolateral plasma membra
ne
 IEA cellular component
GO:0005923 bicellular tight junction
 IEA cellular component
GO:0016323 basolateral plasma membra
ne
 IEA cellular component
GO:0005923 bicellular tight junction
 IEA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:0005923 bicellular tight junction
 ISS cellular component
GO:0042802 identical protein binding
 ISS molecular function
GO:0016338 calcium-independent cell-
cell adhesion via plasma
membrane cell-adhesion mo
lecules
 ISS biological process

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa05130Pathogenic Escherichia coli infection
hsa04530Tight junction
hsa04514Cell adhesion molecules
hsa05160Hepatitis C
hsa04670Leukocyte transendothelial migration

Diseases

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Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract