• Gene id: 135295

Gene Summary

• Gene Symbol: SRSF12   Gene   UCSC   Ensembl
• Aliases: SFRS13B, SFRS19, SRrp35
• Gene name: serine and arginine rich splicing factor 12
• Alternate names: serine/arginine-rich splicing factor 12, 35 kDa SR repressor protein, SR splicing factor 12, serine-arginine repressor protein (35 kDa), splicing factor, arginine/serine-rich 13B, splicing factor, arginine/serine-rich 19,
• Gene location: 6q15 (89118070: 89095956)     Exons: 7     NC_000006.12

Protein Summary

• Protein general information: Q8WXF0  
  • Name: Serine/arginine rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine rich 13B) (Splicing factor, arginine/serine rich 19)
  • Length: 261  
  • Mass: 30512
  • Tissue specificity: Expressed in testis. {ECO
• Sequence:

  MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFEDVRDAEDALYNLNRKW
  VCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDHRRSRSPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQS
  KSRSKSLPRRSTSARQSRTPRRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPC
  KSPKGYTNSETKVQTAKHSHFRSHSRSRSYRHKNSW

• Structural information:
  • Protein Domains: (10..8-)
    (/note="RRM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176"-)
  • Interpro: IPR012677  IPR035979  IPR000504  IPR034477  
  • Prosite: PS50102
  • STRING: ENSP00000414302
• Other Databases: GeneCards:  SRSF12  Malacards:  SRSF12

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0016607	nuclear speck	IBA	cellular component
GO:0045292	mRNA cis splicing, via spliceosome	IBA	biological process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IBA	biological process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IEA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0008380	RNA splicing	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000395	mRNA 5'-splice site recognition	IDA	biological process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	biological process
GO:0050733	RS domain binding	NAS	molecular function
GO:0003723	RNA binding	NAS	molecular function
GO:0000244	spliceosomal tri-snRNP complex assembly	NAS	biological process
GO:0051082	unfolded protein binding	NAS	molecular function
GO:0005654	nucleoplasm	ISS	cellular component
GO:0048025	negative regulation of mRNA splicing, via spliceosome	ISS	biological process
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)