• Gene id: 135

Gene Summary

• Gene Symbol: ADORA2A   Gene   UCSC   Ensembl
• Aliases: A2aR, ADORA2, RDC8
• Gene name: adenosine A2a receptor
• Alternate names: adenosine receptor A2a, adenosine receptor subtype A2a,
• Gene location: 22q11.23 (24423596: 24442359)     Exons: 6     NC_000022.11
• Gene summary(Entrez): This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and
• OMIM: 602462

SNPs

rs2287498

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000017.11   g.7689242C>T
NC_000017.10   g.7592560C>T
NG_017013.2   g.3309G>A
NG_028245.1   g.8172C>T
NM_018081.2   c.450C>T
NM_001143991.2   c.450C>T
NM_001143991.1   c.450C>T
NM_001143992.2   c.450C>T
NM_001143992.1   c.450C>T
NM_001143990.1   c.450C>T
XR_001752551.  

Protein Summary

• Protein general information: P29274  
  • Name: Adenosine receptor A2a
  • Length: 412  
  • Mass: 44707
• Sequence:

  MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH
  GCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPK
  EGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTL
  QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
  KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQ
  GNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

• Structural information:
  • Interpro: IPR001513  IPR001634  IPR000276  IPR017452  
  • Prosite: PS00237 PS50262
  • PDB: 1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6MH8 6PS7
  • PDBsum: 1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6MH8 6PS7
  • STRING: ENSP00000480012
• Other Databases: GeneCards:  ADORA2A  Malacards:  ADORA2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0001609	G protein-coupled adenosine receptor activity	IDA	molecular function
GO:0001609	G protein-coupled adenosine receptor activity	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0019899	enzyme binding	IPI	molecular function
GO:0005887	integral component of plasma membrane	IMP	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0001609	G protein-coupled adenosine receptor activity	IEA	molecular function
GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006915	apoptotic process	TAS	biological process
GO:0006954	inflammatory response	TAS	biological process
GO:0006968	cellular defense response	TAS	biological process
GO:0008015	blood circulation	TAS	biological process
GO:0016020	membrane	TAS	cellular component
GO:0006909	phagocytosis	TAS	biological process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0007417	central nervous system development	TAS	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007600	sensory perception	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0032230	positive regulation of synaptic transmission, GABAergic	IEA	biological process
GO:0050728	negative regulation of inflammatory response	IEA	biological process
GO:0060080	inhibitory postsynaptic potential	IEA	biological process
GO:2001235	positive regulation of apoptotic signaling pathway	IEA	biological process
GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	biological process
GO:0005882	intermediate filament	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0006469	negative regulation of protein kinase activity	IEA	biological process
GO:0007271	synaptic transmission, cholinergic	IEA	biological process
GO:0014049	positive regulation of glutamate secretion	IEA	biological process
GO:0014069	postsynaptic density	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0031000	response to caffeine	IEA	biological process
GO:0031802	type 5 metabotropic glutamate receptor binding	IEA	molecular function
GO:0035810	positive regulation of urine volume	IEA	biological process
GO:0035815	positive regulation of renal sodium excretion	IEA	biological process
GO:0040013	negative regulation of locomotion	IEA	biological process
GO:0042311	vasodilation	IEA	biological process
GO:0042493	response to drug	IEA	biological process
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological process
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0048143	astrocyte activation	IEA	biological process
GO:0048786	presynaptic active zone	IEA	cellular component
GO:0048812	neuron projection morphogenesis	IEA	biological process
GO:0050714	positive regulation of protein secretion	IEA	biological process
GO:0051881	regulation of mitochondrial membrane potential	IEA	biological process
GO:0051899	membrane depolarization	IEA	biological process
GO:0060079	excitatory postsynaptic potential	IEA	biological process
GO:0060134	prepulse inhibition	IEA	biological process
GO:0099056	integral component of presynaptic membrane	IEA	cellular component
GO:1900273	positive regulation of long-term synaptic potentiation	IEA	biological process
GO:0001609	G protein-coupled adenosine receptor activity	IEA	molecular function
GO:0001963	synaptic transmission, dopaminergic	IEA	biological process
GO:0001975	response to amphetamine	IEA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0042755	eating behavior	IEA	biological process
GO:0046636	negative regulation of alpha-beta T cell activation	IEA	biological process
GO:0001609	G protein-coupled adenosine receptor activity	IEA	molecular function
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0012505	endomembrane system	IEA	cellular component
GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	IEA	biological process
GO:0014061	regulation of norepinephrine secretion	IEA	biological process
GO:0030424	axon	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0030673	axolemma	IEA	cellular component
GO:0032279	asymmetric synapse	IEA	cellular component
GO:0035249	synaptic transmission, glutamatergic	IEA	biological process
GO:0042734	presynaptic membrane	IEA	cellular component
GO:0042755	eating behavior	IEA	biological process
GO:0043116	negative regulation of vascular permeability	IEA	biological process
GO:0043279	response to alkaloid	IEA	biological process
GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	IEA	biological process
GO:0051393	alpha-actinin binding	IEA	molecular function
GO:0051924	regulation of calcium ion transport	IEA	biological process
GO:0051968	positive regulation of synaptic transmission, glutamatergic	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0099055	integral component of postsynaptic membrane	IEA	cellular component
GO:2000300	regulation of synaptic vesicle exocytosis	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa05012	Parkinson disease
hsa04015	Rap1 signaling pathway
hsa04024	cAMP signaling pathway
hsa04020	Calcium signaling pathway
hsa05034	Alcoholism
hsa04270	Vascular smooth muscle contraction

Diseases

Associated diseases	References
Asthma	PMID:19019667
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq